Please use this identifier to cite or link to this item: https://doi.org/10.1109/EMBC.2013.6610999
DC FieldValue
dc.titleA simple and effective semi-invasive method for inducing local hypothermia in rat spinal cord
dc.contributor.authorBazley, F.A.
dc.contributor.authorPashai, N.
dc.contributor.authorKerr, C.
dc.contributor.authorThakor, N.
dc.contributor.authorAll, A.H.
dc.date.accessioned2016-10-19T08:44:59Z
dc.date.available2016-10-19T08:44:59Z
dc.date.issued2013
dc.identifier.citationBazley, F.A.,Pashai, N.,Kerr, C.,Thakor, N.,All, A.H. (2013). A simple and effective semi-invasive method for inducing local hypothermia in rat spinal cord. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS : 6321-6324. ScholarBank@NUS Repository. <a href="https://doi.org/10.1109/EMBC.2013.6610999" target="_blank">https://doi.org/10.1109/EMBC.2013.6610999</a>
dc.identifier.isbn9781457702167
dc.identifier.issn1557170X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/128771
dc.description.abstractHypothermia has been shown to be an effective treatment for spinal cord injury. Local hypothermia is advantageous because it avoids inducing systemic side effects of general hypothermia while providing the opportunity for greater temperature reduction at the site of injury, which may contribute to increased neuroprotection. We report a new semi-invasive method for inducing local hypothermia in rats' spinal cords. Our method does not require laminectomy or penetration of the dura and is more effective at cooling the cord than transcutaneous approaches. We show that we were successfully able to cool the spinal cord to 30.2±0.3°C for 2 hours with rectal temperature maintained at 37.3±0.3°C after a spinal cord contusion injury. We also validated our method in control rats that received only a laminectomy. Furthermore, this method was able to reliably cool and rewarm the cord at a steady rate (Δ5.5°C in 30 min, or 0.2°C/min). Future work will include validating long-term functional improvements of injured rats after treatment and to apply local cooling to other spinal cord injury models, such as compression injuries. © 2013 IEEE.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1109/EMBC.2013.6610999
dc.sourceScopus
dc.typeConference Paper
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentELECTRICAL ENGINEERING
dc.description.doi10.1109/EMBC.2013.6610999
dc.description.sourcetitleProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
dc.description.page6321-6324
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Sep 18, 2019

Page view(s)

32
checked on Sep 6, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.