Please use this identifier to cite or link to this item: https://doi.org/10.1902/jop.2013.130238
Title: Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: A preliminary study
Authors: Chang, P.-C.
Chong, L.Y.
Tsai, S.-C.
Lim, L.P. 
Keywords: Advanced
Animal
Gene expression
Glycosylation end products
Inflammation
Models
Periodontitis
X-ray microtomography
Issue Date: 2014
Citation: Chang, P.-C., Chong, L.Y., Tsai, S.-C., Lim, L.P. (2014). Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: A preliminary study. Journal of Periodontology 85 (5) : 729-739. ScholarBank@NUS Repository. https://doi.org/10.1902/jop.2013.130238
Abstract: Advanced glycation end products (AGE) have been found in inflamed gingival tissue and have been shown to interfere with the integrity of extracellular matrix and cell-matrix interactions. This study aims to investigate the modulatory effect of aminoguanidine (AG), an AGE inhibitor, in various stages of experimental periodontitis. Methods: Thirty-six Sprague-Dawley rats were used. AG or normal saline (NS) was systemically administered in the induction, progression, and recovery phases of ligature-induced periodontitis. Dynamic changes of the periodontium were evaluated by microcomputed tomography, histology, and immunohistochemistry of the receptor for AGE (RAGE). Molecular mechanisms were evaluated by myeloperoxidase activity, gene expression of RAGE, and markers associated with tissue repair and homeostasis, including vascular endothelial growth factor (VEGF), type I collagen, fibronectin, and periostin. Results: AG appeared to inhibit the degradation of the collagen matrix in the induction phase but promoted collagen reorganization in the progression and recovery phases of experimental periodontitis. In the induction sites, periodontal bone loss was significantly reduced (P
Source Title: Journal of Periodontology
URI: http://scholarbank.nus.edu.sg/handle/10635/128565
ISSN: 00223492
DOI: 10.1902/jop.2013.130238
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