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Title: Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013
Authors: Teo, J.W.P.
Tan, P.
La, M.-V.
Krishnan, P.
Tee, N.
Koh, T.H.
Deepak, R.N.
Tan, T.Y.
Jureen, R. 
Lin, R.T.P. 
Keywords: Antibiotic resistance
Issue Date: 2014
Citation: Teo, J.W.P., Tan, P., La, M.-V., Krishnan, P., Tee, N., Koh, T.H., Deepak, R.N., Tan, T.Y., Jureen, R., Lin, R.T.P. (2014). Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013. Journal of Global Antimicrobial Resistance 2 (2) : 99-102. ScholarBank@NUS Repository.
Abstract: Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1 mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. blaNDM was the most common (130/400; 32.5%), followed by blaOXA-48-like (blaOXA-48, -181, -232) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab® rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers. © 2013 International Society for Chemotherapy of Infection and Cancer.
Source Title: Journal of Global Antimicrobial Resistance
ISSN: 22137173
DOI: 10.1016/j.jgar.2013.11.003
Appears in Collections:Staff Publications

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