Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpobgyn.2012.06.008
DC FieldValue
dc.titleThe promise of fetal cells in maternal blood
dc.contributor.authorChoolani, M.
dc.contributor.authorMahyuddin, A.P.
dc.contributor.authorHahn, S.
dc.date.accessioned2016-09-07T03:10:11Z
dc.date.available2016-09-07T03:10:11Z
dc.date.issued2012-10
dc.identifier.citationChoolani, M., Mahyuddin, A.P., Hahn, S. (2012-10). The promise of fetal cells in maternal blood. Best Practice and Research: Clinical Obstetrics and Gynaecology 26 (5) : 655-667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpobgyn.2012.06.008
dc.identifier.issn15216934
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/127009
dc.description.abstractDelaying childbirth increases the proportion of advanced maternal age pregnancies. This increases the number of pregnancies requiring invasive prenatal testing. Prenatal diagnosis of chromosomal aneuploidies and monogenic disorders requires fetal cells obtained through invasive procedures (i.e. chorionic villus sampling and amniocentesis). These procedures carry a risk of fetal loss, which causes anxiety to at-risk couples. Intact fetal cells entering maternal circulation have raised the possibility of non-invasive prenatal diagnosis. Rarity of fetal cells, however, has made it challenging. Fetal nucleated red blood cells are ideal candidate target cells because they have limited lifespan, contain true representation of fetal genotype, contain specific fetal cell identifiers (embryonic and fetal globins), and allow interrogation with chromosomal fluorescence in-situ hybridisation and possibly with array comparative genomic hybridisation. The utility of fetal nucleated red blood cells in non-invasive prenatal diagnosis has not reached clinical application because of the inconsistencies in enrichment strategies and rarity of cells. © 2012 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bpobgyn.2012.06.008
dc.sourceScopus
dc.subjectchromosomal FISH
dc.subjectepsilon-globin
dc.subjectfetal nucleated red blood cells
dc.subjectmaternal blood
dc.subjectnon-invasive prenatal diagnosis
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.bpobgyn.2012.06.008
dc.description.sourcetitleBest Practice and Research: Clinical Obstetrics and Gynaecology
dc.description.volume26
dc.description.issue5
dc.description.page655-667
dc.description.codenBPRCF
dc.identifier.isiut000309031900011
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