Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijrobp.2010.08.015
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dc.titlePatient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres
dc.contributor.authorLau, W.-Y.
dc.contributor.authorKennedy, A.S.
dc.contributor.authorKim, Y.H.
dc.contributor.authorLai, H.K.
dc.contributor.authorLee, R.-C.
dc.contributor.authorLeung, T.W.T.
dc.contributor.authorLiu, C.-S.
dc.contributor.authorSalem, R.
dc.contributor.authorSangro, B.
dc.contributor.authorShuter, B.
dc.contributor.authorWang, S.-C.
dc.date.accessioned2016-09-06T09:10:16Z
dc.date.available2016-09-06T09:10:16Z
dc.date.issued2012-01-01
dc.identifier.citationLau, W.-Y., Kennedy, A.S., Kim, Y.H., Lai, H.K., Lee, R.-C., Leung, T.W.T., Liu, C.-S., Salem, R., Sangro, B., Shuter, B., Wang, S.-C. (2012-01-01). Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres. International Journal of Radiation Oncology Biology Physics 82 (1) : 401-407. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijrobp.2010.08.015
dc.identifier.issn03603016
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126952
dc.description.abstractPurpose: Selective internal radiotherapy (SIRT) with yttrium-90 ( 90Y) resin microspheres can improve the clinical outcomes for selected patients with inoperable liver cancer. This technique involves intra-arterial delivery of β-emitting microspheres into hepatocellular carcinomas or liver metastases while sparing uninvolved structures. Its unique mode of action, including both 90Y brachytherapy and embolization of neoplastic microvasculature, necessitates activity planning methods specific to SIRT. Methods and Materials: A panel of clinicians experienced in 90Y resin microsphere SIRT was convened to integrate clinical experience with the published data to propose an activity planning pathway for radioembolization. Results: Accurate planning is essential to minimize potentially fatal sequelae such as radiation-induced liver disease while delivering tumoricidal 90Y activity. Planning methods have included empiric dosing according to degree of tumor involvement, empiric dosing adjusted for the body surface area, and partition model calculations using Medical Internal Radiation Dose principles. It has been recommended that at least two of these methods be compared when calculating the microsphere activity for each patient. Conclusions: Many factors inform 90Y resin microsphere SIRT activity planning, including the therapeutic intent, tissue and vasculature imaging, tumor and uninvolved liver characteristics, previous therapies, and localization of the microsphere infusion. The influence of each of these factors has been discussed. Copyright © 2012 Elsevier Inc. Printed in the USA. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijrobp.2010.08.015
dc.sourceScopus
dc.subjectInterventional radiology
dc.subjectLiver neoplasms
dc.subjectMicrospheres
dc.subjectRadiation dosage
dc.subjectYttrium radioisotopes
dc.typeArticle
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.description.doi10.1016/j.ijrobp.2010.08.015
dc.description.sourcetitleInternational Journal of Radiation Oncology Biology Physics
dc.description.volume82
dc.description.issue1
dc.description.page401-407
dc.description.codenIOBPD
dc.identifier.isiut000298526100058
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