Please use this identifier to cite or link to this item:
Title: Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres
Authors: Lau, W.-Y.
Kennedy, A.S.
Kim, Y.H.
Lai, H.K.
Lee, R.-C.
Leung, T.W.T.
Liu, C.-S.
Salem, R.
Sangro, B.
Shuter, B. 
Wang, S.-C.
Keywords: Interventional radiology
Liver neoplasms
Radiation dosage
Yttrium radioisotopes
Issue Date: 1-Jan-2012
Citation: Lau, W.-Y., Kennedy, A.S., Kim, Y.H., Lai, H.K., Lee, R.-C., Leung, T.W.T., Liu, C.-S., Salem, R., Sangro, B., Shuter, B., Wang, S.-C. (2012-01-01). Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres. International Journal of Radiation Oncology Biology Physics 82 (1) : 401-407. ScholarBank@NUS Repository.
Abstract: Purpose: Selective internal radiotherapy (SIRT) with yttrium-90 ( 90Y) resin microspheres can improve the clinical outcomes for selected patients with inoperable liver cancer. This technique involves intra-arterial delivery of β-emitting microspheres into hepatocellular carcinomas or liver metastases while sparing uninvolved structures. Its unique mode of action, including both 90Y brachytherapy and embolization of neoplastic microvasculature, necessitates activity planning methods specific to SIRT. Methods and Materials: A panel of clinicians experienced in 90Y resin microsphere SIRT was convened to integrate clinical experience with the published data to propose an activity planning pathway for radioembolization. Results: Accurate planning is essential to minimize potentially fatal sequelae such as radiation-induced liver disease while delivering tumoricidal 90Y activity. Planning methods have included empiric dosing according to degree of tumor involvement, empiric dosing adjusted for the body surface area, and partition model calculations using Medical Internal Radiation Dose principles. It has been recommended that at least two of these methods be compared when calculating the microsphere activity for each patient. Conclusions: Many factors inform 90Y resin microsphere SIRT activity planning, including the therapeutic intent, tissue and vasculature imaging, tumor and uninvolved liver characteristics, previous therapies, and localization of the microsphere infusion. The influence of each of these factors has been discussed. Copyright © 2012 Elsevier Inc. Printed in the USA. All rights reserved.
Source Title: International Journal of Radiation Oncology Biology Physics
ISSN: 03603016
DOI: 10.1016/j.ijrobp.2010.08.015
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 2, 2021


checked on Mar 2, 2021

Page view(s)

checked on Mar 6, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.