Please use this identifier to cite or link to this item: https://doi.org/10.1160/TH12-01-0039
Title: Translational platelet research in patients with coronary artery disease: What are the major knowledge gaps?
Authors: Gurbel, P.A.
Roe, M.T.
Jakubowski, J.A.
Shah, S.
Erlinge, D.
Goodman, S.G.
Huber, K.
Chan, M.Y. 
Cornel, J.H.
Tantry, U.S.
Magnus Ohman, E.
Keywords: ADP receptors
Antiplatelet drugs
Clinical trials
Coronary syndrome
Platelet pharmacology
Issue Date: Jul-2012
Citation: Gurbel, P.A., Roe, M.T., Jakubowski, J.A., Shah, S., Erlinge, D., Goodman, S.G., Huber, K., Chan, M.Y., Cornel, J.H., Tantry, U.S., Magnus Ohman, E. (2012-07). Translational platelet research in patients with coronary artery disease: What are the major knowledge gaps?. Thrombosis and Haemostasis 108 (1) : 12-20. ScholarBank@NUS Repository. https://doi.org/10.1160/TH12-01-0039
Abstract: Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. Recent studies have highlighted the relation of single nucleotide polymorphisms of genes involved in clopidogrel absorption and metabolism to reduced pharmacokinetic and pharmacodynamic responses to clopidogrel. CYP 2C19 loss-of-function (LoF) allele carriage has been associated with increased thrombotic risk in the PCI population. However, there is no information regarding the utility of platelet function testing to predict outcomes in patients with stable coronary artery disease and in medically managed patients with acute coronary syndromes. Additionally, few studies have included longitudinal assessment of platelet function to assess a potential timedependent relation to ischaemic event occurrence and no phase-III antiplatelet-therapy trial has included a large enough platelet function sub-study to examine the relation between on-treatment platelet reactivity, bleeding, and ischaemic event occurrence. Therefore, futher studies are needed to delineate the role of platelet function testing across the spectrum of symptomatic coronary artery disease. © Schattauer 2012.
Source Title: Thrombosis and Haemostasis
URI: http://scholarbank.nus.edu.sg/handle/10635/126938
ISSN: 03406245
DOI: 10.1160/TH12-01-0039
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

7
checked on Sep 12, 2019

WEB OF SCIENCETM
Citations

6
checked on Sep 12, 2019

Page view(s)

26
checked on Sep 6, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.