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Title: Japanese encephalitis: Update on vaccines and vaccine recommendations
Authors: Wilder-Smith, A. 
Halstead, S.
Keywords: Advisory committee on immunization practices
chimeric Japanese encephalitis vaccine
inactivated Japanese encephalitis vaccine IC51
Japanese encephalitis
Issue Date: Oct-2010
Citation: Wilder-Smith, A., Halstead, S. (2010-10). Japanese encephalitis: Update on vaccines and vaccine recommendations. Current Opinion in Infectious Diseases 23 (5) : 426-431. ScholarBank@NUS Repository.
Abstract: Purpose of review: Japanese encephalitis is the most common vaccine-preventable viral encephalitis in Asia. In view of the production cessation of the inactivated mouse brain-derived Japanese encephalitis vaccine, it is timely to provide an update on new Japanese encephalitis vaccines and revised vaccine recommendations. Recent findings: A new inactivated, adjuvanted, Vero cell-culture-based Japanese encephalitis vaccine, IC51, was licensed in Europe and the United States in 2009. Administered in a two-dose regimen at 0 and 28 days, it was shown to be well tolerated and produce high seroconversion rates. In addition, Chimerivax Japanese encephalitis, a novel live-attenuated one-dose chimeric vaccine comprising the structural genes of SA 14-14-2 virus and nonstructural genes of yellow fever 17D virus, is in the process of getting licensed in Australia and in south east Asia. Summary: Previous recommendations for Japanese encephalitis vaccination of travelers were predicated on minimizing exposure to a mouse-brain-derived vaccine with a poorly understood and worrisome safety profile, whereas the risk of acquiring Japanese encephalitis itself during travel was assessed to be relatively low. With the availability of a new cell-culture-derived vaccine IC51 with an excellent safety profile, it is appropriate to reconsider benefit-risk considerations for the vaccination of travelers. These considerations are reflected in the March 2010 revised recommendations by the United States Advisory Committee on Immunization Practices. © 2010 Lippincott Williams & Wilkins.
Source Title: Current Opinion in Infectious Diseases
ISSN: 09517375
DOI: 10.1097/QCO.0b013e32833c1d01
Appears in Collections:Staff Publications

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