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Title: Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
Authors: Kim, D.H.
Choi, J.-Y.
Kim, H.W.
Kim, S.H.
Chung, D.R.
Peck, K.R.
Thamlikitkul, V.
So, T.M.-K.
Yasin, R.M.D.
Hsueh, P.-R.
Carlos, C.C.
Hsu, L.Y. 
Buntaran, L.
Lalitha, M.K.
Song, J.-H.
Ko, K.S.
Issue Date: Nov-2013
Citation: Kim, D.H., Choi, J.-Y., Kim, H.W., Kim, S.H., Chung, D.R., Peck, K.R., Thamlikitkul, V., So, T.M.-K., Yasin, R.M.D., Hsueh, P.-R., Carlos, C.C., Hsu, L.Y., Buntaran, L., Lalitha, M.K., Song, J.-H., Ko, K.S. (2013-11). Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands. Antimicrobial Agents and Chemotherapy 57 (11) : 5239-5246. ScholarBank@NUS Repository.
Abstract: In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Source Title: Antimicrobial Agents and Chemotherapy
ISSN: 00664804
DOI: 10.1128/AAC.00633-13
Appears in Collections:Staff Publications

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