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|Title:||Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: The TRILOGY ACS platelet function substudy||Authors:||Gurbel, P.A.
|Issue Date:||7-Nov-2012||Citation:||Gurbel, P.A., Erlinge, D., Ohman, E.M., Neely, B., Neely, M., Goodman, S.G., Huber, K., Chan, M.Y., Cornel, J.H., Brown, E., Zhou, C., Jakubowski, J.A., White, H.D., Fox, K.A.A., Prabhakaran, D., Armstrong, P.W., Tantry, U.S., Roe, M.T. (2012-11-07). Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: The TRILOGY ACS platelet function substudy. JAMA - Journal of the American Medical Association 308 (17) : 1785-1794. ScholarBank@NUS Repository. https://doi.org/10.1001/jama.2012.17312||Abstract:||Context: The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective: To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel. Design, Setting, and Patients: Patients with medically managed unstable angina or non-ST-segment elevationmyocardial infarction were enrolled in the TRILOGY ACS trial (2008 to 2011) comparing clopidogrel vs prasugrel. Of 9326 participants, 27.5% were included in a platelet function substudy: 1286 treated with prasugrel and 1278 treated with clopidogrel. Interventions: Aspirin with either prasugrel (10 or 5 mg/d) or clopidogrel (75 mg/d); those 75 years or older and younger than 75 years but who weighed less than 60 kg received a 5-mg prasugrel maintenance dose. Main Outcome Measures: Platelet reactivity, measured in P2Y12 reaction units (PRUs), was performed at baseline, at 2 hours, and at 1, 3, 6, 12, 18, 24, and 30 months after randomization. The primary efficacy end point was a composite of cardiovascular death, myocardial infarction, or stroke through 30 months. Results: Among participants younger than 75 years and weighing 60 kg or more, the median PRU values at 30 days were 64 (interquartile range [IQR], 33-128) in the prasugrel group vs 200 (IQR, 141-260) in the clopidogrel group (P||Source Title:||JAMA - Journal of the American Medical Association||URI:||http://scholarbank.nus.edu.sg/handle/10635/126837||ISSN:||00987484||DOI:||10.1001/jama.2012.17312|
|Appears in Collections:||Staff Publications|
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