Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijantimicag.2010.08.002
Title: In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: Results of the COMPACT Asia-Pacific Study
Authors: Christiansen, K.J.
Ip, M.
Ker, H.B.
Mendoza, M.
Hsu, L. 
Kiratisin, P.
Chongthaleong, A.
Redjeki, I.S.
Quintana, A.
Flamm, R.
Garcia, J.
Cassettari, M.
Cooper, D.
Okolo, P.
Morrissey, I.
Keywords: Carbapenem
Doripenem
Enterobacteriaceae
Gram-negative
Pseudomonas
Surveillance
Issue Date: Dec-2010
Citation: Christiansen, K.J., Ip, M., Ker, H.B., Mendoza, M., Hsu, L., Kiratisin, P., Chongthaleong, A., Redjeki, I.S., Quintana, A., Flamm, R., Garcia, J., Cassettari, M., Cooper, D., Okolo, P., Morrissey, I. (2010-12). In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: Results of the COMPACT Asia-Pacific Study. International Journal of Antimicrobial Agents 36 (6) : 501-506. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijantimicag.2010.08.002
Abstract: The Comparative Activity of Carbapenems Testing (COMPACT) Study was designed to determine the in vitro potency of doripenem compared with imipenem and meropenem against a large number of contemporary Gram-negative pathogens from more than 100 centres across Europe and the Asia-Pacific region and to assess the reliability of Etest methodology for doripenem minimum inhibitory concentration (MIC) determination against these pathogens. Data from eight countries within the Asia-Pacific region, which collected 1612 bacterial isolates, are presented here. Etest methodology was found to be a reliable method for MIC determination. Doripenem showed in vitro activity similar to or better than meropenem and at least four-fold better than imipenem against Enterobacteriaceae. Against Pseudomonas aeruginosa, doripenem was also the most active of the three carbapenems in vitro. However, in vitro results do not necessarily correlate with clinical outcome. © 2010 Elsevier B.V. and the International Society of Chemotherapy.
Source Title: International Journal of Antimicrobial Agents
URI: http://scholarbank.nus.edu.sg/handle/10635/126821
ISSN: 09248579
DOI: 10.1016/j.ijantimicag.2010.08.002
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