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Title: Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency
Authors: Lam, C.S.P. 
Shah, A.M.
Borlaug, B.A.
Cheng, S.
Verma, A.
Izzo, J.
Oparil, S.
Aurigemma, G.P.
Thomas, J.D.
Pitt, B.
Zile, M.R.
Solomon, S.D.
Keywords: Arterial stiffness
Ventricular stiffness
Issue Date: 1-Mar-2013
Citation: Lam, C.S.P., Shah, A.M., Borlaug, B.A., Cheng, S., Verma, A., Izzo, J., Oparil, S., Aurigemma, G.P., Thomas, J.D., Pitt, B., Zile, M.R., Solomon, S.D. (2013-03-01). Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. European Heart Journal 34 (9) : 676-683. ScholarBank@NUS Repository.
Abstract: AimsTo investigate the effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency in early-stage hypertension.Methods and resultsWe studied 527 participants from two clinical trials assessing the effect of blood pressure lowering on diastolic function. Participants were aged ≥45 years with early-stage hypertension, no heart failure, ejection fraction (EF) ≥50%, and diastolic dysfunction using Doppler echocardiography. Effective arterial afterload and its components were assessed along with measures of left ventricular (LV) structure and function prior to and after 24-38 weeks of antihypertensive therapy. Systolic blood pressure decreased from 154 ± 18 to 137 ± 15 mmHg at follow-up. Blood pressure reduction was associated with decreases in ventricular and arterial stiffness, improvements in systemic arterial compliance and resistance, enhanced LV ejection, and reduction in cardiac work (all P < 0.001). Changes in Ea/Ees ratio were inversely correlated with those in EF (r = -0.25; P < 0.001), stroke work index (r = -0.13; P = 0.007), and LV efficiency (r = -0.98; P < 0.001); and directly related to changes in mitral E/e′ (r = 0.12; P = 0.01). Adjusting for age and blood pressure change, women and obese individuals had less enhancement in ventricular-arterial coupling and efficiency compared with men and non-obese individuals (P = 0.04 and 0.007, respectively).ConclusionAntihypertensive therapy reduces arterial and ventricular stiffness, enhances ventricular-arterial coupling, reduces cardiac work, and improves LV efficiency, systolic, and diastolic function. Attenuated responses in women and among obese subjects suggest that structure-function changes may be less reversible in these groups, possibly explaining their greater susceptibility to ultimately develop heart failure. © 2012 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2012. For permissions please email: journals.permissions@oup. com.
Source Title: European Heart Journal
ISSN: 0195668X
DOI: 10.1093/eurheartj/ehs299
Appears in Collections:Staff Publications

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