Please use this identifier to cite or link to this item:
Title: Conversion to enteric-coated mycophenolate sodium from mycophenolate mofetil in stable renal transplant patients: Results of an Asia-Pacific study
Authors: Lee, P.-H.
Vathsala, A. 
Han, D.J.
Chan, T.-M.
Wong, H.-S.
Woodcock, C.
Kurstjens, N.
Keywords: clinical trial
immune suppression
Issue Date: Jan-2013
Citation: Lee, P.-H., Vathsala, A., Han, D.J., Chan, T.-M., Wong, H.-S., Woodcock, C., Kurstjens, N. (2013-01). Conversion to enteric-coated mycophenolate sodium from mycophenolate mofetil in stable renal transplant patients: Results of an Asia-Pacific study. Nephrology 18 (1) : 57-62. ScholarBank@NUS Repository.
Abstract: Aim Mycophenolate mofetil has proven efficacy in the prophylaxis of acute rejection in solid organ transplantation; however, gastrointestinal intolerance can risk this efficacy because of associated dose adjustments and discontinued treatment. Enteric-coated mycophenolate sodium has demonstrated improved gastrointestinal tolerability, but the data in Asian subjects are scarce. Methods This was a Phase-IIIb, open-label, single-arm, multicentre, prospective 6-month study which investigated safety and graft function in stable maintenance renal transplant recipients of Asian origin, after switching from mycophenolate mofetil to enteric-coated mycophenolate sodium at least 3 months after transplantation. Primary end-points included renal allograft function and safety parameters. Results The study recruited patients from 16 centres in Asian countries. The intention-to-treat and safety populations both included 122 patients. Graft function remained stable over the course of the study as measured by creatinine clearance and glomerular filtration rate. At 6 months the incidence of any gastrointestinal adverse events was 20.5% (n = 25), none of which required dose adjustments. There were only three cases of biopsy proven acute rejection with no reports of graft loss or death. Conclusion This study demonstrated that enteric-coated mycophenolate sodium is a safe and effective alternative to mycophenolate mofetil in Asian kidney transplant recipients. © 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Source Title: Nephrology
ISSN: 13205358
DOI: 10.1111/nep.12007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 15, 2021


checked on Jan 5, 2021

Page view(s)

checked on Jan 16, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.