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Title: Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme
Authors: Yin, D.
Chen, W.
O'Kelly, J.
Lu, D.
Ham, M.
Doan, N.B.
Xie, D.
Wang, C.
Vadgama, J.
Said, J.W.
Black, K.L.
Koeffler, H.P. 
Keywords: CCN
drug resistance
glioblastoma multiforme (GBM)
Issue Date: 15-Nov-2010
Citation: Yin, D., Chen, W., O'Kelly, J., Lu, D., Ham, M., Doan, N.B., Xie, D., Wang, C., Vadgama, J., Said, J.W., Black, K.L., Koeffler, H.P. (2010-11-15). Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. International Journal of Cancer 127 (10) : 2257-2267. ScholarBank@NUS Repository.
Abstract: Connective tissue growth factor (CTGF or CCN2) is a secreted protein that belongs to the CCN [cysteine-rich CYR61/CTGF/nephroblastoma-overexpressed gene] family. These proteins have been implicated in various biological processes, including stimulation of cell proliferation, migration, angiogenesis and tumorigenesis. In a previous study, we found that CTGF mRNA was elevated in primary gliomas, and a significant correlation existed between CTGF mRNA levels versus tumor grade, histology and patient survival. In this study, the role of CTGF in glioma tumorigenesis was explored. Forced expression of CTGF in glioblastoma multiforme (GBM) cells accelerated their growth in liquid culture and soft agar, stimulated cells migration in Boyden chamber assays and significantly increased their ability to form large, vascularized tumors in nude mice. CTGF induced the expression of the antiapoptotic proteins, Bcl-xl, Survivin and Flip. Overexpression of CTGF caused the U343 GBM cells to survive for longer than 40 days in serum-free medium and resist antitumor drugs including tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand, VELCADE (bortezomib, proteasome inhibitor) and temozolomide. Our data suggest that CTGF plays an important role in glioma progression, by supporting tumor cells survival and drug resistance. © 2010 UICC.
Source Title: International Journal of Cancer
ISSN: 00207136
DOI: 10.1002/ijc.25257
Appears in Collections:Staff Publications

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