Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.25257
Title: Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme
Authors: Yin, D.
Chen, W.
O'Kelly, J.
Lu, D.
Ham, M.
Doan, N.B.
Xie, D.
Wang, C.
Vadgama, J.
Said, J.W.
Black, K.L.
Koeffler, H.P. 
Keywords: CCN
CTGF
drug resistance
glioblastoma multiforme (GBM)
Issue Date: 15-Nov-2010
Citation: Yin, D., Chen, W., O'Kelly, J., Lu, D., Ham, M., Doan, N.B., Xie, D., Wang, C., Vadgama, J., Said, J.W., Black, K.L., Koeffler, H.P. (2010-11-15). Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. International Journal of Cancer 127 (10) : 2257-2267. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.25257
Abstract: Connective tissue growth factor (CTGF or CCN2) is a secreted protein that belongs to the CCN [cysteine-rich CYR61/CTGF/nephroblastoma-overexpressed gene] family. These proteins have been implicated in various biological processes, including stimulation of cell proliferation, migration, angiogenesis and tumorigenesis. In a previous study, we found that CTGF mRNA was elevated in primary gliomas, and a significant correlation existed between CTGF mRNA levels versus tumor grade, histology and patient survival. In this study, the role of CTGF in glioma tumorigenesis was explored. Forced expression of CTGF in glioblastoma multiforme (GBM) cells accelerated their growth in liquid culture and soft agar, stimulated cells migration in Boyden chamber assays and significantly increased their ability to form large, vascularized tumors in nude mice. CTGF induced the expression of the antiapoptotic proteins, Bcl-xl, Survivin and Flip. Overexpression of CTGF caused the U343 GBM cells to survive for longer than 40 days in serum-free medium and resist antitumor drugs including tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand, VELCADE (bortezomib, proteasome inhibitor) and temozolomide. Our data suggest that CTGF plays an important role in glioma progression, by supporting tumor cells survival and drug resistance. © 2010 UICC.
Source Title: International Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/126798
ISSN: 00207136
DOI: 10.1002/ijc.25257
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

45
checked on Jan 21, 2022

WEB OF SCIENCETM
Citations

46
checked on Jan 21, 2022

Page view(s)

82
checked on Jan 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.