Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.gie.2010.08.031
Title: Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study
Authors: Li, Z.
Yu, T.
Zuo, X.-L.
Gu, X.-M.
Zhou, C.-J.
Ji, R.
Li, C.-Q.
Wang, P.
Zhang, T.-G.
Ho, K.-Y. 
Li, Y.-Q.
Keywords: Abbreviations
CI
CLE
Confidence interval
Confocal laser endomicroscopy
Gastric intraepithelial neoplasia
GIN
HGIN
High-grade intraepithelial neoplasia
INS
Intraepithelial neoplasia score
LGIN
Low-grade intraepithelial neoplasia
ROC
Issue Date: Dec-2010
Citation: Li, Z., Yu, T., Zuo, X.-L., Gu, X.-M., Zhou, C.-J., Ji, R., Li, C.-Q., Wang, P., Zhang, T.-G., Ho, K.-Y., Li, Y.-Q. (2010-12). Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study. Gastrointestinal Endoscopy 72 (6) : 1146-1153. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gie.2010.08.031
Abstract: Background Confocal laser endomicroscopy (CLE) is a novel endoscopic modality that allows subsurface analysis of the gastric mucosa during ongoing endoscopy. Several studies have reported that this technique is of value in the diagnosis of premalignant lesions in the GI tract, but as yet no investigations have reported its application in the analysis of gastric intraepithelial neoplasia (GIN). Objective To assess the feasibility of CLE for the identification and grading of GIN. Design Prospective double-blind feasibility study. Setting Qilu Hospital, Shandong University, Jinan, China. Patients CLE images of 33 patients were first evaluated to establish the diagnostic criteria for gastric lesions. Eligible patients were then prospectively investigated by CLE using the newly established criteria. Interventions All endoscopically suspicious lesions were examined by CLE, and CLE diagnoses were compared with corresponding histopathologic results. Main Outcome Measurements Sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of biopsy-proven intraepithelial neoplasia by per-lesion analysis. Results The sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of GIN were 77.8%, 81.8%, 4.28, and 0.27, respectively. The mean κ value for interobserver agreement for the diagnosis of GIN was 0.70 among endoscopists and 0.71 between endoscopist and GI pathologist. Intraepithelial neoplasia score
Source Title: Gastrointestinal Endoscopy
URI: http://scholarbank.nus.edu.sg/handle/10635/126797
ISSN: 00165107
DOI: 10.1016/j.gie.2010.08.031
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