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|Title:||Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study||Authors:||Li, Z.
Confocal laser endomicroscopy
Gastric intraepithelial neoplasia
High-grade intraepithelial neoplasia
Intraepithelial neoplasia score
Low-grade intraepithelial neoplasia
|Issue Date:||Dec-2010||Citation:||Li, Z., Yu, T., Zuo, X.-L., Gu, X.-M., Zhou, C.-J., Ji, R., Li, C.-Q., Wang, P., Zhang, T.-G., Ho, K.-Y., Li, Y.-Q. (2010-12). Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study. Gastrointestinal Endoscopy 72 (6) : 1146-1153. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gie.2010.08.031||Abstract:||Background Confocal laser endomicroscopy (CLE) is a novel endoscopic modality that allows subsurface analysis of the gastric mucosa during ongoing endoscopy. Several studies have reported that this technique is of value in the diagnosis of premalignant lesions in the GI tract, but as yet no investigations have reported its application in the analysis of gastric intraepithelial neoplasia (GIN). Objective To assess the feasibility of CLE for the identification and grading of GIN. Design Prospective double-blind feasibility study. Setting Qilu Hospital, Shandong University, Jinan, China. Patients CLE images of 33 patients were first evaluated to establish the diagnostic criteria for gastric lesions. Eligible patients were then prospectively investigated by CLE using the newly established criteria. Interventions All endoscopically suspicious lesions were examined by CLE, and CLE diagnoses were compared with corresponding histopathologic results. Main Outcome Measurements Sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of biopsy-proven intraepithelial neoplasia by per-lesion analysis. Results The sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of GIN were 77.8%, 81.8%, 4.28, and 0.27, respectively. The mean κ value for interobserver agreement for the diagnosis of GIN was 0.70 among endoscopists and 0.71 between endoscopist and GI pathologist. Intraepithelial neoplasia score||Source Title:||Gastrointestinal Endoscopy||URI:||http://scholarbank.nus.edu.sg/handle/10635/126797||ISSN:||00165107||DOI:||10.1016/j.gie.2010.08.031|
|Appears in Collections:||Staff Publications|
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