Please use this identifier to cite or link to this item: https://doi.org/10.3892/ol.2013.1262
Title: Can quantifying free-circulating DNA in plasma be used to identify subjects with high-grade pre-invasive endobronchial lesions?
Authors: Van Boerdonk, R.A.A.
Brokx, H.A.P.
Lee, P. 
Kooi, C.
Postmus, P.E.
Snijders, P.J.F.
Grünberg, K.
Thunnissen, E.
Sutedja, T.G.
Daniels, J.M.A.
Heideman, D.A.M.
Keywords: Autofluorescence bronchoscopy
Circulating plasma DNA
Premalignant endobronchial lesion
Issue Date: Oct-2013
Citation: Van Boerdonk, R.A.A., Brokx, H.A.P., Lee, P., Kooi, C., Postmus, P.E., Snijders, P.J.F., Grünberg, K., Thunnissen, E., Sutedja, T.G., Daniels, J.M.A., Heideman, D.A.M. (2013-10). Can quantifying free-circulating DNA in plasma be used to identify subjects with high-grade pre-invasive endobronchial lesions?. Oncology Letters 5 (5) : 1591-1594. ScholarBank@NUS Repository. https://doi.org/10.3892/ol.2013.1262
Abstract: Increased concentrations of free-circulating plasma DNA (cpDNA) are observed in patients with invasive cancer, including lung cancer. Whether cpDNA levels are elevated in subjects with high-grade pre-invasive lesions of lung squamous cell carcinoma (SqCC) and whether its detection may be of value for identifying subjects at the highest risk of developing lung SqCC is currently unknown. The present study assessed cpDNA levels in subjects with high- and low--grade pre-invasive squamous endobronchial lesions relative to patients with clinically overt lung SqCC and healthy controls using real-time quantitative PCR methodology. The median cpDNA levels of the patients with invasive lung SqCC (n=16) were significantly higher compared with those of the healthy controls (n=16; P
Source Title: Oncology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/126790
ISSN: 17921074
DOI: 10.3892/ol.2013.1262
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