Please use this identifier to cite or link to this item: https://doi.org/10.1155/2012/640894
DC FieldValue
dc.titleRetrovirus entry by endocytosis and cathepsin proteases
dc.contributor.authorKubo, Y.
dc.contributor.authorHayashi, H.
dc.contributor.authorMatsuyama, T.
dc.contributor.authorSato, H.
dc.contributor.authorYamamoto, N.
dc.date.accessioned2016-09-06T08:19:41Z
dc.date.available2016-09-06T08:19:41Z
dc.date.issued2012
dc.identifier.citationKubo, Y., Hayashi, H., Matsuyama, T., Sato, H., Yamamoto, N. (2012). Retrovirus entry by endocytosis and cathepsin proteases. Advances in Virology 2012 : -. ScholarBank@NUS Repository. https://doi.org/10.1155/2012/640894
dc.identifier.issn16878639
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126776
dc.description.abstractRetroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells. Understanding the entry mechanism of retroviruses contributes to developments of novel therapeutic approaches against retrovirus-induced diseases and efficient exploitation of retroviral vectors. Entry of enveloped viruses into host cell cytoplasm is achieved by fusion between the viral envelope and host cell membranes at either the cell surface or intracellular vesicles. Many animal retroviruses enter host cells through endosomes and require endosome acidification. Ecotropic murine leukemia virus entry requires cathepsin proteases activated by the endosome acidification. CD4-dependent human immunodeficiency virus (HIV) infection is thought to occur via endosomes, but endosome acidification is not necessary for the entry whereas entry of CD4-independent HIVs, which are thought to be prototypes of CD4-dependent viruses, is low pH dependent. There are several controversial results on the retroviral entry pathways. Because endocytosis and endosome acidification are complicatedly controlled by cellular mechanisms, the retrovirus entry pathways may be different in different cell lines. © 2012 Yoshinao Kubo et al.
dc.sourceScopus
dc.typeReview
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1155/2012/640894
dc.description.sourcetitleAdvances in Virology
dc.description.volume2012
dc.description.page-
dc.identifier.isiut000299917400009
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