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Title: Brd4 and HEXIM1: Multiple roles in P-TEFb regulation and cancer
Authors: Chen, R.
Yik, J.H.N.
Lew, Q.J.
Chao, S.-H. 
Issue Date: 2014
Citation: Chen, R., Yik, J.H.N., Lew, Q.J., Chao, S.-H. (2014). Brd4 and HEXIM1: Multiple roles in P-TEFb regulation and cancer. BioMed Research International 2014 : -. ScholarBank@NUS Repository.
Abstract: Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb's transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer. © 2014 Ruichuan Chen et al.
Source Title: BioMed Research International
ISSN: 23146133
DOI: 10.1155/2014/232870
Appears in Collections:Staff Publications

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