Please use this identifier to cite or link to this item:
|Title:||Serial nerve conduction studies provide insight into the pathophysiology of Guillain-Barré and Fisher syndromes||Authors:||Shahrizaila, N.
|Keywords:||Acute inflammatory demyelinating polyneuropathy
Acute motor axonal neuropathy
Nerve conduction study
|Issue Date:||15-Oct-2011||Citation:||Shahrizaila, N., Goh, K.J., Kokubun, N., Abdullah, S., Yuki, N. (2011-10-15). Serial nerve conduction studies provide insight into the pathophysiology of Guillain-Barré and Fisher syndromes. Journal of the Neurological Sciences 309 (1-2) : 26-30. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2011.07.042||Abstract:||The electrodiagnosis of Guillain-Barré syndrome (GBS) can be broadly divided into acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Fisher syndrome (FS) is a variant of GBS, although the underlying neuropathy of FS has yet to be established. Serial nerve conduction studies (NCS) can provide further insight into the likely pathophysiology by further subtyping of GBS and FS. We present a patient with an initial diagnosis of AIDP in whom repeated NCS revealed the AMAN variant. This led us to investigate serial NCS in five patients with GBS, FS and FS/GBS overlap presenting over a period of a year. Three patients with AIDP showed a gradual increase in distal motor latencies during the acute phase of illness. NCS of two patients with FS and FS/GBS overlap showed no demyelinating features suggesting underlying axonal neuropathy in this group of patients. The importance of serial NCS in establishing the underlying pattern of neuropathy in GBS and FS is further emphasized in this study. Larger studies incorporating serial NCS are required to confirm the observations seen in our case series especially when pathological studies are often not justified in this group of patients. © 2011 Elsevier B.V. All rights reserved.||Source Title:||Journal of the Neurological Sciences||URI:||http://scholarbank.nus.edu.sg/handle/10635/126749||ISSN:||0022510X||DOI:||10.1016/j.jns.2011.07.042|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 13, 2019
WEB OF SCIENCETM
checked on Jun 5, 2019
checked on May 25, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.