Please use this identifier to cite or link to this item: https://doi.org/10.2217/fmb.12.134
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dc.titlePeptide targeting and imaging of damaged lung tissue in influenza-infected mice
dc.contributor.authorLi, N.
dc.contributor.authorYin, L.
dc.contributor.authorThévenin, D.
dc.contributor.authorYamada, Y.
dc.contributor.authorLimmon, G.
dc.contributor.authorChen, J.
dc.contributor.authorChow, V.T.K.
dc.contributor.authorEngelman, D.M.
dc.contributor.authorEngelward, B.P.
dc.date.accessioned2016-09-06T08:19:20Z
dc.date.available2016-09-06T08:19:20Z
dc.date.issued2013-02
dc.identifier.citationLi, N., Yin, L., Thévenin, D., Yamada, Y., Limmon, G., Chen, J., Chow, V.T.K., Engelman, D.M., Engelward, B.P. (2013-02). Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiology 8 (2) : 257-269. ScholarBank@NUS Repository. https://doi.org/10.2217/fmb.12.134
dc.identifier.issn17460913
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126745
dc.description.abstractAim: In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. Materials & methods: Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. Results: pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. Conclusion: pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue. © 2013 Future Medicine Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2217/fmb.12.134
dc.sourceScopus
dc.subjectdelivery
dc.subjectinflammation
dc.subjectinfluenza
dc.subjectpeptide
dc.subjectpHLIP
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.2217/fmb.12.134
dc.description.sourcetitleFuture Microbiology
dc.description.volume8
dc.description.issue2
dc.description.page257-269
dc.identifier.isiut000314579800015
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