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Title: Peptide targeting and imaging of damaged lung tissue in influenza-infected mice
Authors: Li, N.
Yin, L.
Thévenin, D.
Yamada, Y.
Limmon, G.
Chen, J.
Chow, V.T.K. 
Engelman, D.M.
Engelward, B.P.
Keywords: delivery
Issue Date: Feb-2013
Citation: Li, N., Yin, L., Thévenin, D., Yamada, Y., Limmon, G., Chen, J., Chow, V.T.K., Engelman, D.M., Engelward, B.P. (2013-02). Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiology 8 (2) : 257-269. ScholarBank@NUS Repository.
Abstract: Aim: In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. Materials & methods: Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. Results: pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. Conclusion: pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue. © 2013 Future Medicine Ltd.
Source Title: Future Microbiology
ISSN: 17460913
DOI: 10.2217/fmb.12.134
Appears in Collections:Staff Publications

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