Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0027849
DC Field | Value | |
---|---|---|
dc.title | Partial depletion of natural CD4 +CD25 + regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza a virus infection | |
dc.contributor.author | Betts, R.J. | |
dc.contributor.author | Ho, A.W.S. | |
dc.contributor.author | Kemeny, D.M. | |
dc.date.accessioned | 2016-09-06T08:19:19Z | |
dc.date.available | 2016-09-06T08:19:19Z | |
dc.date.issued | 2011-11-18 | |
dc.identifier.citation | Betts, R.J., Ho, A.W.S., Kemeny, D.M. (2011-11-18). Partial depletion of natural CD4 +CD25 + regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza a virus infection. PLoS ONE 6 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0027849 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/126744 | |
dc.description.abstract | Foxp3 + CD4 + regulatory T cells represent a T cell subset with well-characterized immunosuppressive effects during immune homeostasis and chronic infections, and there is emerging evidence to suggest these cells temper pulmonary inflammation in response to acute viral infection. Recent studies have demonstrated treatment with PC61 CD25-depleting antibody potentiates inflammation in a murine model of RSV infection, while paradoxically delaying recruitment of CD8 + T cells to the site of inflammation. The present study therefore sought to examine the role of these cells in a murine model of acute influenza A virus infection through the administration of PC61 CD25-depleting antibody. PC61 antibody is able to partially deplete CD25 +Foxp3 + regulatory T cells to a comparable degree as seen within previous work examining RSV, however this does not alter influenza A-virus induced mortality, weight loss, viral clearance and cellularity within the lung. Collectively, these data demonstrate that partial depletion of CD4 +CD25 + regulatory T cells with PC61 antibody does not alter the course of influenza A virus infection. © 2011 Betts et al. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0027849 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY | |
dc.description.doi | 10.1371/journal.pone.0027849 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 6 | |
dc.description.issue | 11 | |
dc.description.page | - | |
dc.identifier.isiut | 000297789200030 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pone_0027849.pdf | 577.48 kB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.