Please use this identifier to cite or link to this item:
|Title:||Complement Mediated Signaling on Pulmonary CD103+ Dendritic Cells Is Critical for Their Migratory Function in Response to Influenza Infection||Authors:||Kandasamy, M.
|Issue Date:||Jan-2013||Citation:||Kandasamy, M., Ying, P.C., Ho, A.W.S., Sumatoh, H.R., Schlitzer, A., Hughes, T.R., Kemeny, D.M., Morgan, B.P., Ginhoux, F., Sivasankar, B. (2013-01). Complement Mediated Signaling on Pulmonary CD103+ Dendritic Cells Is Critical for Their Migratory Function in Response to Influenza Infection. PLoS Pathogens 9 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1003115||Abstract:||Trafficking of lung dendritic cells (DCs) to the draining lymph node (dLN) is a crucial step for the initiation of T cell responses upon pathogen challenge. However, little is known about the factors that regulate lung DC migration to the dLN. In this study, using a model of influenza infection, we demonstrate that complement component C3 is critically required for efficient emigration of DCs from the lung to the dLN. C3 deficiency affect lung DC-mediated viral antigen transport to the dLN, resulting in severely compromised priming of virus-specific T cell responses. Consequently, C3-deficient mice lack effector T cell response in the lungs that affected viral clearance and survival. We further show that direct signaling by C3a and C5a through C3aR and C5aR respectively expressed on lung DCs is required for their efficient trafficking. However, among lung DCs, only CD103+ DCs make a significant contribution to lung C5a levels and exclusively produce high levels of C3 and C5 during influenza infection. Collectively, our findings show that complement has a profound impact on immune regulation by controlling tissue DC trafficking and highlights a potential utility for complement as an adjuvant in novel vaccine strategies. © 2013 Kandasamy et al.||Source Title:||PLoS Pathogens||URI:||http://scholarbank.nus.edu.sg/handle/10635/126713||ISSN:||15537366||DOI:||10.1371/journal.ppat.1003115|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
|10_1371_journal_ppat_1003115.pdf||2.2 MB||Adobe PDF|
checked on Oct 18, 2019
WEB OF SCIENCETM
checked on Oct 10, 2019
checked on Oct 11, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.