Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2014.03.154
Title: Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus
Authors: Kakoki, K.
Kamiyama, H.
Izumida, M.
Yashima, Y.
Hayashi, H.
Yamamoto, N. 
Matsuyama, T.
Igawa, T.
Sakai, H.
Kubo, Y.
Keywords: Androgen
LNCaP cell
Prostate cancer
XMRV
Issue Date: 25-Apr-2014
Citation: Kakoki, K., Kamiyama, H., Izumida, M., Yashima, Y., Hayashi, H., Yamamoto, N., Matsuyama, T., Igawa, T., Sakai, H., Kubo, Y. (2014-04-25). Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus. Biochemical and Biophysical Research Communications 447 (1) : 216-222. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2014.03.154
Abstract: Xenotropic murine leukemia virus-related virus (XMRV) is a novel gammaretrovirus that was originally isolated from human prostate cancer. It is now believed that XMRV is not the etiologic agent of prostate cancer. An analysis of murine leukemia virus (MLV) infection in various human cell lines revealed that prostate cancer cell lines are preferentially infected by XMRV, and this suggested that XMRV infection may confer some sort of growth advantage to prostate cancer cell lines. To examine this hypothesis, androgen-dependent LNCaP cells were infected with XMRV and tested for changes in certain cell growth properties. We found that XMRV-infected LNCaP cells can proliferate in the absence of the androgen dihydrotestosterone. Moreover, androgen receptor expression is significantly reduced in XMRV-infected LNCaP cells. Such alterations were not observed in uninfected and amphotropic MLV-infected LNCaP cells. This finding explains why prostate cancer cell lines are preferentially infected with XMRV. ©2014 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/126708
ISSN: 10902104
DOI: 10.1016/j.bbrc.2014.03.154
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