Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M110.187989
DC FieldValue
dc.titleA distinct role for pin 1 in the induction and maintenance of pluripotency
dc.contributor.authorNishi, M.
dc.contributor.authorAkutsu, H.
dc.contributor.authorMasui, S.
dc.contributor.authorKondo, A.
dc.contributor.authorNagashima, Y.
dc.contributor.authorKimura, H.
dc.contributor.authorPerrem, K.
dc.contributor.authorShigeri, Y.
dc.contributor.authorToyoda, M.
dc.contributor.authorOkayama, A.
dc.contributor.authorHirano, H.
dc.contributor.authorUmezawa, A.
dc.contributor.authorYamamoto, N.
dc.contributor.authorLee, S.W.
dc.contributor.authorRyoa, A.
dc.date.accessioned2016-09-06T08:18:52Z
dc.date.available2016-09-06T08:18:52Z
dc.date.issued2011-04-01
dc.identifier.citationNishi, M., Akutsu, H., Masui, S., Kondo, A., Nagashima, Y., Kimura, H., Perrem, K., Shigeri, Y., Toyoda, M., Okayama, A., Hirano, H., Umezawa, A., Yamamoto, N., Lee, S.W., Ryoa, A. (2011-04-01). A distinct role for pin 1 in the induction and maintenance of pluripotency. Journal of Biological Chemistry 286 (13) : 11593-11603. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M110.187989
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126705
dc.description.abstractThe prominent characteristics of pluripotent stem cells are their unique capacity to self-renew and pluripotency. Although pluripotent stem cell proliferation is maintained by specific intracellular phosphorylation signaling events, it has not been well characterized how the resulting phosphorylated proteins are subsequently regulated. We here report that the peptidylprolyl isomerase Pin1 is indispensable for the self-renewal and maintenance of pluripotent stem cells via the regulation of phosphorylated Oct4 and other substrates. Pin1 expression was found to be up-regulated upon the induction of induced pluripotent stem (iPS) cells, and the forced expression of Pin1 with defined reprogramming factors was observed to further enhance the frequency of iPS cell generation. The inhibition of Pin1 activity significantly suppressed colony formation and induced the aberrant differentiation of human iPS cells as well as murine ES cells. We further found that Pin1 interacts with the phosphorylated Ser12-Pro motif of Oct4 and that this in turn facilitates the stability and transcriptional activity functions of Oct4. Our current findings thus uncover an atypical role for Pin1 as a putative regulator of the induction and maintenance of pluripotency via the control of phosphorylation signaling. These data suggest that the manipulation of Pin1 function could be a potential strategy for the stable induction and proliferation of human iPS cells. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M110.187989
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1074/jbc.M110.187989
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume286
dc.description.issue13
dc.description.page11593-11603
dc.description.codenJBCHA
dc.identifier.isiut000288797100069
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

25
checked on Sep 6, 2019

WEB OF SCIENCETM
Citations

26
checked on Sep 6, 2019

Page view(s)

28
checked on Sep 6, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.