The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts

Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.536300

Title:	The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts
Authors:	Matsui, H. Fukuno, N. Kanda, Y. Kantoh, Y. Chida, T. Nagaura, Y. Suzuki, O. Nishitoh, H. Takeda, K. Ichijo, H. Sawada, Y. Sasaki, K. Kobayashi, T. Tamura, S.
Issue Date:	7-Mar-2014
Citation:	Matsui, H., Fukuno, N., Kanda, Y., Kantoh, Y., Chida, T., Nagaura, Y., Suzuki, O., Nishitoh, H., Takeda, K., Ichijo, H., Sawada, Y., Sasaki, K., Kobayashi, T., Tamura, S. (2014-03-07). The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. Journal of Biological Chemistry 289 (10) : 6438-6450. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.536300
Abstract:	Background: Fn14 is a highly inducible member of the TNF receptor family. Results: Large-magnitude mechanical stress induced Fn14 expression via JNK in osteoblasts. Conclusion: Expression of Fn14 regulates mechanical stress-induced apoptosis in osteoblasts. Significance: This is the first elucidation of the mechanism of excessive mechanical stress-induced apoptosis mediated by Fn14. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title:	Journal of Biological Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/126623
ISSN:	1083351X
DOI:	10.1074/jbc.M113.536300
Appears in Collections:	Staff Publications

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