Please use this identifier to cite or link to this item:
|Title:||Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma||Authors:||Lee, N.P.
|Issue Date:||Dec-2010||Citation:||Lee, N.P., Poon, R.T.P., Shek, F.H., Ng, I.O.L., Luk, J.M. (2010-12). Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma. Biochimica et Biophysica Acta - Reviews on Cancer 1806 (2) : 138-145. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbcan.2010.05.002||Abstract:||Cadherin is an important cell adhesion molecule that plays paramount roles in organ development and the maintenance of tissue integrity. Dysregulation of cadherin expression is often associated with disease pathology including tissue dysplasia, tumor formation, and metastasis. Cadherin-17 (CDH17), belonging to a subclass of 7D-cadherin superfamily, is present in fetal liver and gastrointestinal tract during embryogenesis, but the gene becomes silenced in healthy adult liver and stomach tissues. It functions as a peptide transporter and a cell adhesion molecule to maintain tissue integrity in epithelia. However, recent findings from our group and others have reported aberrant expression of CDH17 in major gastrointestinal malignancies including hepatocellular carcinoma (HCC), stomach and colorectal cancers, and its clinical association with tumor metastasis and advanced tumor stages. Furthermore, alternative splice isoforms and genetic polymorphisms of CDH17 gene have been identified in HCC and linked to an increased risk of HCC. CDH17 is an attractive target for HCC therapy. Targeting CDH17 in HCC can inhibit tumor growth and inactivate Wnt signaling pathway in concomitance with activation of tumor suppressor genes. Further investigation on CDH17-mediated oncogenic signaling and cognate molecular mechanisms would shed light on new targeting therapy on HCC and potentially other gastrointestinal malignancies. © 2010 Elsevier B.V.||Source Title:||Biochimica et Biophysica Acta - Reviews on Cancer||URI:||http://scholarbank.nus.edu.sg/handle/10635/125894||ISSN:||0304419X||DOI:||10.1016/j.bbcan.2010.05.002|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 21, 2020
WEB OF SCIENCETM
checked on Oct 21, 2020
checked on Oct 17, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.