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Title: Review of juxtaglomerular cell tumor with focus on pathobiological aspect
Authors: Kuroda, N.
Gotoda, H.
Ohe, C.
Mikami, S.
Inoue, K.
Nagashima, Y.
Petersson, F. 
Alvarado-Cabrero, I.
Pan, C.-C.
Hes, O.
Michal, M.
Gatalica, Z.
Issue Date: 26-Aug-2011
Citation: Kuroda, N., Gotoda, H., Ohe, C., Mikami, S., Inoue, K., Nagashima, Y., Petersson, F., Alvarado-Cabrero, I., Pan, C.-C., Hes, O., Michal, M., Gatalica, Z. (2011-08-26). Review of juxtaglomerular cell tumor with focus on pathobiological aspect. Diagnostic Pathology 6 (1) : -. ScholarBank@NUS Repository.
Abstract: Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. © 2011 Kuroda et al; licensee BioMed Central Ltd.
Source Title: Diagnostic Pathology
ISSN: 17461596
DOI: 10.1186/1746-1596-6-80
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