Please use this identifier to cite or link to this item:
|Title:||Unmet medical needs in systemic lupus erythematosus||Authors:||Lateef, A.
|Issue Date:||18-Dec-2012||Citation:||Lateef, A., Petri, M. (2012-12-18). Unmet medical needs in systemic lupus erythematosus. Arthritis Research and Therapy 14 (SUPPL. 4) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/ar3919||Abstract:||Systemic lupus erythematosus (SLE) is an autoimmune disease of diverse manifestations, with onset usually in young women in the third to fourth decade of life. The chronic nature of this relapsing remitting disease leads to organ damage accrual over time. Mortality and morbidity are increased in patients with SLE compared with the general population. Therapeutic advances over the last few decades have led to significant improvements in patient outcomes. Five-year survival has improved to over 90% from a low of 50% in the 1950s. However, multiple aspects of the management of SLE patients are still far from optimal. Early diagnosis remains a challenge; diagnostic delays leading to delay in definitive treatment are common. Monitoring treatment remains problematic due to the paucity of sensitive biomarkers. Current treatment regimens rely heavily on corticosteroids, even though corticosteroids are well known to cause organ damage. Treatment of refractory disease manifestations such as nephritis, recalcitrant cutaneous lesions and neurological involvement require new approaches with greater efficacy. Cognitive dysfunction is common in SLE patients, but early recognition and adequate treatment are yet to be established. Premature accelerated atherosclerosis remains a leading cause of morbidity and mortality. Fatigue is one of the most disabling symptoms, and contributes to the poor quality of life in patients with SLE. Ongoing research in SLE faces many challenges, including enrollment of homogeneous patient populations, use of reliable outcome measures and a standard control arm. The current review will highlight some of the outstanding unmet challenges in the management of this complex disease. © 2012 BioMed Central Ltd.||Source Title:||Arthritis Research and Therapy||URI:||http://scholarbank.nus.edu.sg/handle/10635/125869||ISSN:||14786354||DOI:||10.1186/ar3919|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 19, 2022
WEB OF SCIENCETM
checked on May 19, 2022
checked on May 12, 2022
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.