Please use this identifier to cite or link to this item: https://doi.org/10.3184/003685010X12708274571283
Title: Organ transplantation has come of age
Authors: Calne, R.Y. 
Keywords: Donor shortage
Immunosuppression
Organ transplantation
Issue Date: Jun-2010
Abstract: Organ transplantation started in the mid-1950s with a kidney transplant between identical twins, demonstrating the surgical technique could provide successful therapy. The immunological barrier to be overcome, however, proved to be far more difficult to deal with. The introduction of immunosuppressive agents produced some success but it was not until Cyclosporin became available in the 1980s that results became sufficiently good for widespread acceptance and rapid development of organ grafting. Now with more powerful and selective agents, although there is still much room for improvement in immunosuppression, one of the main problems in organ transplantation is a result of its success, namely a shortage of organ donors. In this review, I summarise these matters.
Source Title: Science Progress
URI: http://scholarbank.nus.edu.sg/handle/10635/125694
ISSN: 00368504
DOI: 10.3184/003685010X12708274571283
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