Please use this identifier to cite or link to this item:
Title: Cerebral microbleeds and cognition: The epidemiology of dementia in singapore study
Authors: Hilal, S.
Saini, M.
Tan, C.S.
Catindig, J.A.
Koay, W.I.
Niessen, W.J.
Vrooman, H.A.
Wong, T.Y. 
Chen, C. 
Ikram, M.K. 
Venketasubramanian, N.
Keywords: Cerebral microbleeds
Cerebral small vessel disease
Magnetic resonance imaging
Issue Date: 2014
Citation: Hilal, S., Saini, M., Tan, C.S., Catindig, J.A., Koay, W.I., Niessen, W.J., Vrooman, H.A., Wong, T.Y., Chen, C., Ikram, M.K., Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: The epidemiology of dementia in singapore study. Alzheimer Disease and Associated Disorders 28 (2) : 106-112. ScholarBank@NUS Repository.
Abstract: Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs - independent of other traditional markers of cerebral small vessel disease - are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3 T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were - independent of cardiovascular risk factors and other markers of cerebral small vessel disease - significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference per CMB increase: -0.06; 95% confidence interval: -0.11, -0.01] and with domain-specific Z-scores including executive function, attention, and visuoconstruction. Among Chinese subjects CMBs were, independent of other concomitant markers of cerebral small vessel disease, associated with poorer cognitive function. Copyright © 2013 by Lippincott Williams & Wilkins.
Source Title: Alzheimer Disease and Associated Disorders
ISSN: 08930341
DOI: 10.1097/WAD.0000000000000015
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on May 26, 2020


checked on May 26, 2020

Page view(s)

checked on May 29, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.