Please use this identifier to cite or link to this item: https://doi.org/10.1097/WAD.0000000000000015
Title: Cerebral microbleeds and cognition: The epidemiology of dementia in singapore study
Authors: Hilal, S.
Saini, M.
Tan, C.S.
Catindig, J.A.
Koay, W.I.
Niessen, W.J.
Vrooman, H.A.
Wong, T.Y. 
Chen, C. 
Ikram, M.K. 
Venketasubramanian, N.
Keywords: Cerebral microbleeds
Cerebral small vessel disease
Cognition
Magnetic resonance imaging
Issue Date: 2014
Citation: Hilal, S., Saini, M., Tan, C.S., Catindig, J.A., Koay, W.I., Niessen, W.J., Vrooman, H.A., Wong, T.Y., Chen, C., Ikram, M.K., Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: The epidemiology of dementia in singapore study. Alzheimer Disease and Associated Disorders 28 (2) : 106-112. ScholarBank@NUS Repository. https://doi.org/10.1097/WAD.0000000000000015
Abstract: Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs - independent of other traditional markers of cerebral small vessel disease - are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3 T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were - independent of cardiovascular risk factors and other markers of cerebral small vessel disease - significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference per CMB increase: -0.06; 95% confidence interval: -0.11, -0.01] and with domain-specific Z-scores including executive function, attention, and visuoconstruction. Among Chinese subjects CMBs were, independent of other concomitant markers of cerebral small vessel disease, associated with poorer cognitive function. Copyright © 2013 by Lippincott Williams & Wilkins.
Source Title: Alzheimer Disease and Associated Disorders
URI: http://scholarbank.nus.edu.sg/handle/10635/125657
ISSN: 08930341
DOI: 10.1097/WAD.0000000000000015
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