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Title: Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma
Authors: Petersson, F. 
Vijayadwaja, D.
Loh, K.S. 
Tan, K.-B. 
Keywords: Carcinoma
Epstein-Barr virus
Salivary gland carcinoma
Issue Date: 2013
Citation: Petersson, F., Vijayadwaja, D., Loh, K.S., Tan, K.-B. (2013). Reticular and Myxoid Non-keratinizing Nasopharyngeal Carcinoma: An Unusual Case Mimicking a Salivary Gland Carcinoma. Head and Neck Pathology : 1-5. ScholarBank@NUS Repository.
Abstract: We present a case of non-keratinizing carcinoma of the nasopharynx (NK-NPC) with an unusual histopathological pattern. The neoplastic cells were arranged in anastomosing cords embedded in a stroma which contained a significant component of alcian blue-positive myxoid substance forming a reticular pattern. These histopathological features gave an initial impression of a salivary gland-type carcinoma. On immunohistochemistry the tumor cells were strongly and diffusely positive for cytokeratins (AE1-3 and 5/6) and p63 and there was strong and diffuse nuclear positivity for Epstein-Barr virus-encoded small RNA on in situ hybridization. This case highlights the histomorphological variability of NK-NPC. Awareness of the histological spectrum of NK-NPC is important in clinical practice and this is not always adequately highlighted in currently used standard textbooks of Head and Neck Pathology. © 2013 Springer Science+Business Media New York.
Source Title: Head and Neck Pathology
ISSN: 1936055X
DOI: 10.1007/s12105-013-0512-6
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