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Title: The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process
Authors: Petersson, F. 
Branzovsky, J.
Martinek, P.
Korabecna, M.
Kruslin, B.
Hora, M.
Peckova, K.
Bauleth, K.
Pivovarcikova, K.
Michal, M.
Svajdler, M.
Sperga, M.
Bulimbasic, S.
Leroy, X.
Rychly, B.
Trivunic, S.
Kokoskova, B.
Rotterova, P.
Podhola, M.
Suster, S.
Hes, O.
Keywords: HUMARA
Leiomyomatous stroma
Reactive stroma
Renal cell carcinoma
Stroma origin
Issue Date: 18-May-2014
Citation: Petersson, F., Branzovsky, J., Martinek, P., Korabecna, M., Kruslin, B., Hora, M., Peckova, K., Bauleth, K., Pivovarcikova, K., Michal, M., Svajdler, M., Sperga, M., Bulimbasic, S., Leroy, X., Rychly, B., Trivunic, S., Kokoskova, B., Rotterova, P., Podhola, M., Suster, S., Hes, O. (2014-05-18). The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process. Virchows Archiv. ScholarBank@NUS Repository.
Abstract: Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14) cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber veins located at the peripheral capsular region or within the collagenous septae of the tumors. © 2014 Springer-Verlag Berlin Heidelberg.
Source Title: Virchows Archiv
ISSN: 09456317
DOI: 10.1007/s00428-014-1591-9
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