Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.humpath.2012.11.019
DC FieldValue
dc.titleRenal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma
dc.contributor.authorPetersson, F.
dc.contributor.authorGrossmann, P.
dc.contributor.authorHora, M.
dc.contributor.authorSperga, M.
dc.contributor.authorMontiel, D.P.
dc.contributor.authorMartinek, P.
dc.contributor.authorGutierrez, M.E.C.
dc.contributor.authorBulimbasic, S.
dc.contributor.authorMichal, M.
dc.contributor.authorBranzovsky, J.
dc.contributor.authorHes, O.
dc.date.accessioned2016-07-08T09:29:30Z
dc.date.available2016-07-08T09:29:30Z
dc.date.issued2013-07
dc.identifier.citationPetersson, F., Grossmann, P., Hora, M., Sperga, M., Montiel, D.P., Martinek, P., Gutierrez, M.E.C., Bulimbasic, S., Michal, M., Branzovsky, J., Hes, O. (2013-07). Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. Human Pathology 44 (7) : 1412-1420. ScholarBank@NUS Repository. https://doi.org/10.1016/j.humpath.2012.11.019
dc.identifier.issn00468177
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125632
dc.description.abstractWe present a cohort of 8 renal carcinomas that displayed a variable (5%-95% extent) light microscopic appearance of renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma (RAT/CCPRCC) without fulfilling the criteria for these tumors. All but 1 case predominantly (75%-95% extent) showed histopathologic features of conventional clear cell renal cell carcinoma. In 5 of 7 cases with mostly conventional clear renal cell carcinoma (CRCC) morphology, a diagnosis of CRCC was supported by the molecular genetic findings (presence of von Hippel-Lindau tumor suppressor [VHL] mutation and/or VHL promoter methylation and/or loss of heterozygosity [LOH] for 3p). Of the other 2 cases with predominantly characteristic CRCC morphology, 1 tumor did not reveal any VHL mutation, VHL promoter methylation, or LOH for 3p, and both chromosomes 7 and 17 were disomic, whereas the other tumor displayed polysomy for chromosomes 7 and 17 and no VHL mutation, VHL promoter methylation, or LOH for 3p. One tumor was composed primarily (95%) of distinctly RAT/CCPRCC-like morphology, and this tumor harbored a VHL mutation and displayed polysomy for chromosomes 7 and 17. Of the 5 cases with both histomorphologic features and molecular genetic findings of CRCC, we detected significant immunoreactivity for α-methylacyl-CoA racemase in 2 cases and strong diffuse immunopositivity for cytokeratin 7 in 3 cases. Despite the combination of positivity for α-methylacyl-CoA racemase and cytokeratin 7 in 2 cases, there was nothing to suggest of the possibility of a conventional papillary renal cell carcinoma with a predominance of clear cells. © 2013 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.humpath.2012.11.019
dc.sourceScopus
dc.subjectClear cell papillary renal cell carcinoma
dc.subjectClear renal cell carcinoma
dc.subjectImmunohistochemistry
dc.subjectMolecular genetics
dc.subjectRenal angiomyomatous tumor
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1016/j.humpath.2012.11.019
dc.description.sourcetitleHuman Pathology
dc.description.volume44
dc.description.issue7
dc.description.page1412-1420
dc.description.codenHPCQA
dc.identifier.isiut000321225000025
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

36
checked on Nov 30, 2021

WEB OF SCIENCETM
Citations

33
checked on Nov 30, 2021

Page view(s)

87
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.