Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.humpath.2012.11.019
DC Field | Value | |
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dc.title | Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma | |
dc.contributor.author | Petersson, F. | |
dc.contributor.author | Grossmann, P. | |
dc.contributor.author | Hora, M. | |
dc.contributor.author | Sperga, M. | |
dc.contributor.author | Montiel, D.P. | |
dc.contributor.author | Martinek, P. | |
dc.contributor.author | Gutierrez, M.E.C. | |
dc.contributor.author | Bulimbasic, S. | |
dc.contributor.author | Michal, M. | |
dc.contributor.author | Branzovsky, J. | |
dc.contributor.author | Hes, O. | |
dc.date.accessioned | 2016-07-08T09:29:30Z | |
dc.date.available | 2016-07-08T09:29:30Z | |
dc.date.issued | 2013-07 | |
dc.identifier.citation | Petersson, F., Grossmann, P., Hora, M., Sperga, M., Montiel, D.P., Martinek, P., Gutierrez, M.E.C., Bulimbasic, S., Michal, M., Branzovsky, J., Hes, O. (2013-07). Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. Human Pathology 44 (7) : 1412-1420. ScholarBank@NUS Repository. https://doi.org/10.1016/j.humpath.2012.11.019 | |
dc.identifier.issn | 00468177 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/125632 | |
dc.description.abstract | We present a cohort of 8 renal carcinomas that displayed a variable (5%-95% extent) light microscopic appearance of renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma (RAT/CCPRCC) without fulfilling the criteria for these tumors. All but 1 case predominantly (75%-95% extent) showed histopathologic features of conventional clear cell renal cell carcinoma. In 5 of 7 cases with mostly conventional clear renal cell carcinoma (CRCC) morphology, a diagnosis of CRCC was supported by the molecular genetic findings (presence of von Hippel-Lindau tumor suppressor [VHL] mutation and/or VHL promoter methylation and/or loss of heterozygosity [LOH] for 3p). Of the other 2 cases with predominantly characteristic CRCC morphology, 1 tumor did not reveal any VHL mutation, VHL promoter methylation, or LOH for 3p, and both chromosomes 7 and 17 were disomic, whereas the other tumor displayed polysomy for chromosomes 7 and 17 and no VHL mutation, VHL promoter methylation, or LOH for 3p. One tumor was composed primarily (95%) of distinctly RAT/CCPRCC-like morphology, and this tumor harbored a VHL mutation and displayed polysomy for chromosomes 7 and 17. Of the 5 cases with both histomorphologic features and molecular genetic findings of CRCC, we detected significant immunoreactivity for α-methylacyl-CoA racemase in 2 cases and strong diffuse immunopositivity for cytokeratin 7 in 3 cases. Despite the combination of positivity for α-methylacyl-CoA racemase and cytokeratin 7 in 2 cases, there was nothing to suggest of the possibility of a conventional papillary renal cell carcinoma with a predominance of clear cells. © 2013 Elsevier Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.humpath.2012.11.019 | |
dc.source | Scopus | |
dc.subject | Clear cell papillary renal cell carcinoma | |
dc.subject | Clear renal cell carcinoma | |
dc.subject | Immunohistochemistry | |
dc.subject | Molecular genetics | |
dc.subject | Renal angiomyomatous tumor | |
dc.type | Article | |
dc.contributor.department | PATHOLOGY | |
dc.description.doi | 10.1016/j.humpath.2012.11.019 | |
dc.description.sourcetitle | Human Pathology | |
dc.description.volume | 44 | |
dc.description.issue | 7 | |
dc.description.page | 1412-1420 | |
dc.description.coden | HPCQA | |
dc.identifier.isiut | 000321225000025 | |
Appears in Collections: | Staff Publications |
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