Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.13-12476
Title: Progressive myopia or hyperopia can be induced in chicks and reversed by manipulation of the chromaticity of ambient light
Authors: Foulds, W.S.
Barathi, V.A. 
Luu, C.D.
Keywords: Animal model
Myopia
Refractive error
Issue Date: 12-Nov-2013
Citation: Foulds, W.S., Barathi, V.A., Luu, C.D. (2013-11-12). Progressive myopia or hyperopia can be induced in chicks and reversed by manipulation of the chromaticity of ambient light. Investigative Ophthalmology and Visual Science 54 (13) : 8004-8012. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.13-12476
Abstract: Purpose. To determine whether progressive ametropia can be induced in chicks and reversed by manipulation of the chromaticity of ambient light. Methods. One-day-old chicks were raised in red light (90% red, 10% yellow-green) or in blue light (85% blue, 15% green) with a 12 hour on/off cycle for 14 to 42 days. Refraction was determined by streak retinoscopy, and by automated infrared photoretinoscopy and ocular biometry by A-scan ultrasonography. Results. Red light induced progressive myopia (mean refraction ± SD at 28 days, -2.83 ± 0.25 diopters [D]). Progressive hyperopia was induced by blue light (mean refraction at 28 days, +4.55 ± 0.21 D). The difference in refraction between the groups was highly significant at P < 0.001. Induced myopia or hyperopia was axial as confirmed by ultrasound biometry. Myopia induced by 21 days of red light (-2.21 ± 0.21 D) was reversed to hyperopia (+2.50 ± 0.29 D) by subsequent 21 days of blue light. Hyperopia induced by 21 days of blue light (+4.21 ± 0.19 D) was reversed to myopia (-1.23 ± 0.12 D) by 21 days of red light. Conclusions. Rearing chicks in red light caused progressive myopia, while rearing in blue light caused progressive hyperopia. Light-induced myopia or hyperopia in chicks can be reversed to hyperopia or myopia, respectively, by an alteration in the chromaticity of ambient light. Manipulation of chromaticity may be applicable to the management of human childhood myopia. © 2013 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/125558
ISSN: 01460404
DOI: 10.1167/iovs.13-12476
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

54
checked on Apr 21, 2021

WEB OF SCIENCETM
Citations

43
checked on Apr 21, 2021

Page view(s)

71
checked on Apr 10, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.