Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.526210
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dc.titleApelin attenuates Oxidative stress in human Adipocytes
dc.contributor.authorThan, A.
dc.contributor.authorZhang, X.
dc.contributor.authorLeow, M.K.-S.
dc.contributor.authorPoh, C.L.
dc.contributor.authorChong, S.K.
dc.contributor.authorChen, P.
dc.date.accessioned2016-07-08T09:28:22Z
dc.date.available2016-07-08T09:28:22Z
dc.date.issued2014-02-07
dc.identifier.citationThan, A., Zhang, X., Leow, M.K.-S., Poh, C.L., Chong, S.K., Chen, P. (2014-02-07). Apelin attenuates Oxidative stress in human Adipocytes. Journal of Biological Chemistry 289 (6) : 3763-3774. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.526210
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125537
dc.description.abstractBackground: Antioxidant effects of apelin on adipocytes are unknown. Results: Apelin not only suppresses production and release of reactive oxygen species, but also relieves oxidative-stress induced cellular dysfunctions in adipocytes. Conclusion: Apelin-APJ signaling acts as the negative autocrine feedbacks against oxidative stress in adipocytes. Significance: Apelin signaling may serve as a potential therapeutic target for metabolic disorders. It has been recently recognized that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor to the pathogenesis of obesity-Associated metabolic diseases. Apelin is an adipocytokine secreted by adipocytes, and known for its anti-obesity and anti-diabetic properties. In obesity, both oxidative stress and plasma level of apelin are increased. However, the regulatory roles of apelin on oxidative stress in adipocytes remain unknown. In the present study, we provide evidence that apelin, through its interaction with apelin receptor (APJ), suppresses production and release of reactive oxygen species (ROS) in adipocytes. This is further supported by the observations that apelin promotes the expression of antioxidant enzymes via MAPK kinase/ERK and AMPK pathways, and suppresses the expression of pro-oxidant enzyme via AMPK pathway. We further demonstrate that apelin is able to relieve oxidative stress-induced dysregulations of the expression of anti- and pro-oxidant enzymes, mitochondrial biogenesis and function, as well as release of pro- and anti-inflammatory adipocytokines. This study, for the first time, reveals the antioxidant properties of apelin in adipocytes, and suggests its potential as a novel therapeutic target for metabolic diseases.© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M113.526210
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1074/jbc.M113.526210
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume289
dc.description.issue6
dc.description.page3763-3774
dc.description.codenJBCHA
dc.identifier.isiut000331368700056
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