Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.joen.2011.06.017
DC FieldValue
dc.titleRole of efflux pump inhibitors on the antibiofilm efficacy of calcium hydroxide, chitosan nanoparticles, and light-activated disinfection
dc.contributor.authorUpadya, M.
dc.contributor.authorShrestha, A.
dc.contributor.authorKishen, A.
dc.date.accessioned2016-07-08T09:28:06Z
dc.date.available2016-07-08T09:28:06Z
dc.date.issued2011-10
dc.identifier.citationUpadya, M., Shrestha, A., Kishen, A. (2011-10). Role of efflux pump inhibitors on the antibiofilm efficacy of calcium hydroxide, chitosan nanoparticles, and light-activated disinfection. Journal of Endodontics 37 (10) : 1422-1426. ScholarBank@NUS Repository. https://doi.org/10.1016/j.joen.2011.06.017
dc.identifier.issn00992399
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125515
dc.description.abstractIntroduction: The purpose of this study was to evaluate the role of efflux pumps in altering the susceptibility of Enterococcus faecalis biofilms to calcium hydroxide (Ca(OH) 2), chitosan nanoparticles, and light-activated disinfection (LAD). Methods: E. faecalis as 4-day-old biofilms and biofilm-derived cells were tested with aqueous Ca(OH) 2 in concentrations of 25%, 50%, and 100%; chitosan nanoparticles in concentrations of 10 and 20 mg/mL (3, 12, and 24 hours); and methylene blue (MB) mediated LAD at an energy dose range of 2-40 J/cm 2. An efflux pump inhibitor (EPI) was incorporated into all 3 modalities of treatment. The antimicrobial activity was assessed by determining the colony-forming units. Results: E. faecalis biofilms, in contrast to the biofilm-derived cells, were found to persist even after 24-hour treatment with different concentrations of Ca(OH) 2 and chitosan nanoparticles. LAD at an energy dose of 40 J/cm 2 completely inactivated 4-day-old E. faecalis biofilms. The addition of EPI improved the antibiofilm efficacy of Ca(OH) 2 at lower concentrations (P
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.joen.2011.06.017
dc.sourceScopus
dc.subjectBiofilm
dc.subjectcalcium hydroxide
dc.subjectefflux
dc.subjectEnterococcus faecalis
dc.subjectlight activated disinfection
dc.subjectnanoparticles
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.joen.2011.06.017
dc.description.sourcetitleJournal of Endodontics
dc.description.volume37
dc.description.issue10
dc.description.page1422-1426
dc.description.codenJOEND
dc.identifier.isiut000295661800018
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.