Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/125514
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dc.titleRecombinant baculovirus displayed vaccine a novel tool for the development of a cross-protective influenza H5N1 vaccine
dc.contributor.authorPrabakaran, M.
dc.contributor.authorKwang, J.
dc.date.accessioned2016-07-08T09:28:05Z
dc.date.available2016-07-08T09:28:05Z
dc.date.issued2013-08-09
dc.identifier.issn19491018
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125514
dc.description.abstractThe rapid evolution of new sublineages of H5N1 influenza in Asia poses the greatest challenge in vaccine development for pre-pandemic preparedness. To overcome the antigenic diversity of H5N1 strains, multiple vaccine strains can be designed based on the distribution of neutralizing epitopes in the globular head of H5 hemagglutinin (HA). Recently, we selected two different HAs of H5N1 strains based on the neutralizing epitopes and reactivity with different neutralizing antibodies. The HAs of selected vaccine strains were individually expressed on the baculovirus envelope (bivalent-BacHA) with its native antigenic configuration. Further, oral delivery of live bivalent-BacHA elicited broadly reactive humoral, mucosal and cell-mediated immune responses and showed complete protection against antigenically distinct H5N1 strains in mice. The strategy for the vaccine strain selection, vaccine design and route of administration will provide an idea for development of a widely protective vaccine against highly pathogenic H5N1 for pre-pandemic preparedness. © 2014 Landes Bioscience.
dc.sourceScopus
dc.subjectCellular immunity
dc.subjectCross-protection
dc.subjectH5N1
dc.subjectPrepandemic
dc.subjectVaccine selection
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.sourcetitleBioengineered
dc.description.volume5
dc.description.issue1
dc.description.page-
dc.identifier.isiutNOT_IN_WOS
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