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|Title:||Neuromuscular transmission is not impaired in axonal Guillain-Barré syndrome||Authors:||Kuwabara, S.
|Issue Date:||Oct-2011||Citation:||Kuwabara, S., Kokubun, N., Misawa, S., Kanai, K., Isose, S., Shibuya, K., Noto, Y., Mori, M., Sekiguchi, Y., Nasu, S., Fujimaki, Y., Hirata, K., Yuki, N. (2011-10). Neuromuscular transmission is not impaired in axonal Guillain-Barré syndrome. Journal of Neurology, Neurosurgery and Psychiatry 82 (10) : 1174-1177. ScholarBank@NUS Repository. https://doi.org/10.1136/jnnp.2010.210708||Abstract:||Background: Previous studies have shown that anti-GQ1b antibodies induce massive neuromuscular blocking. If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain-Barré syndrome (GBS). Methods: Axonal-stimulating single-fibre electromyography was performed in the extensor digitorum communis muscle of 23 patients with GBS, including 13 with the axonal form whose sera had a high titre of serum IgG anti-GM1 or -GD1a antibodies. Results: All patients with axonal or demyelinating GBS showed normal or near-normal jitter, and no blocking. Conclusion: In both axonal and demyelinating GBS, neuromuscular transmission is not impaired. Our results failed to support the hypothesis that anti-GM1 or -GD1a antibody affects the NMJ. In GBS, impulse transmission is presumably impaired in the motor nerve terminal axons proximal to the NMJ.||Source Title:||Journal of Neurology, Neurosurgery and Psychiatry||URI:||http://scholarbank.nus.edu.sg/handle/10635/125508||ISSN:||00223050||DOI:||10.1136/jnnp.2010.210708|
|Appears in Collections:||Staff Publications|
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