Please use this identifier to cite or link to this item: https://doi.org/10.1136/jnnp.2010.205856
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dc.titleIVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy
dc.contributor.authorYuki, N.
dc.contributor.authorWatanabe, H.
dc.contributor.authorNakajima, T.
dc.contributor.authorSpäth, P.J.
dc.date.accessioned2016-07-08T09:27:59Z
dc.date.available2016-07-08T09:27:59Z
dc.date.issued2011-01
dc.identifier.citationYuki, N., Watanabe, H., Nakajima, T., Späth, P.J. (2011-01). IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 82 (1) : 87-91. ScholarBank@NUS Repository. https://doi.org/10.1136/jnnp.2010.205856
dc.identifier.issn00223050
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125505
dc.description.abstractBackground: The pathogenesis of multifocal motor neuropathy (MMN) has yet to be established. MMN patients often carry anti-GM1 IgM antibodies, suggesting an autoimmune process involving complement. Intravenous immunoglobulin (IVIG) is the first line treatment, but its action mechanism is unknown. Objective: To test whether anti-GM1 IgM antibodies in MMN sera activate complement, inducing and propagating the disease and whether IVIG inhibits complement activation, resulting in clinical improvement. Methods: Sera with anti-GM1 IgM but not IgG or IgA reactivity were obtained from 13 patients with MMN. We tested whether their anti-GM1 IgM antibodies produced complement component deposits on GM1- coated microtiter plates and whether IVIG blocks such deposition. Results: C1q, C4b, C3b and C5b-9 were deposited on GM1-coated wells. Their depositions were highly correlated with anti-GM1 IgM antibody titre. IVIG reduced the deposition of these complement components dose-dependently. Conclusions: Anti-GM1 IgM antibodies bound to GM1 and activated complement in vitro. The results together with earlier data from our group suggest that IgMinduced, complement-mediated injury occurs at the nodes of Ranvier in peripheral motor nerves and generates conduction block and muscle weakness. In vitro IVIG inhibited this type of complement activation, suggesting that in vivo, the resulting reduction in membrane attack complex-mediated damage leads to improved muscle strength.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1136/jnnp.2010.205856
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1136/jnnp.2010.205856
dc.description.sourcetitleJournal of Neurology, Neurosurgery and Psychiatry
dc.description.volume82
dc.description.issue1
dc.description.page87-91
dc.description.codenJNNPA
dc.identifier.isiut000285183000021
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