Please use this identifier to cite or link to this item: https://doi.org/10.1136/jnnp.2010.226639
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dc.titleGuillain-Barré syndrome subtypes related to Campylobacter infection
dc.contributor.authorDrenthen, J.
dc.contributor.authorYuki, N.
dc.contributor.authorMeulstee, J.
dc.contributor.authorMaathuis, E.M.
dc.contributor.authorVan Doorn, P.A.
dc.contributor.authorVisser, G.H.
dc.contributor.authorBlok, J.H.
dc.contributor.authorJacobs, B.C.
dc.date.accessioned2016-07-08T09:27:54Z
dc.date.available2016-07-08T09:27:54Z
dc.date.issued2011-03
dc.identifier.citationDrenthen, J., Yuki, N., Meulstee, J., Maathuis, E.M., Van Doorn, P.A., Visser, G.H., Blok, J.H., Jacobs, B.C. (2011-03). Guillain-Barré syndrome subtypes related to Campylobacter infection. Journal of Neurology, Neurosurgery and Psychiatry 82 (3) : 300-305. ScholarBank@NUS Repository. https://doi.org/10.1136/jnnp.2010.226639
dc.identifier.issn00223050
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125499
dc.description.abstractBackground: In Guillain-Barré syndrome (GBS), the diversity in electrophysiological subtypes is unexplained but may be determined by geographical factors and preceding infections. Acute motor axonal neuropathy (AMAN) is a frequent GBS variant in Japan and one study proposed that in Japan, Campylobacter jejuni infections exclusively elicit AMAN. In The Netherlands C jejuni is the predominant type of preceding infection yet AMAN is rare. This may indicate that not all Dutch GBS patients with C jejuni infections have AMAN. Objective: To determine if GBS patients with a preceding C jejuni infection in The Netherlands exclusively have AMAN. Methods: Retrospective analysis of preceding infections in relation to serial electrophysiology and clinical data from 123 GBS patients. C jejuni related cases were defined as having preceding diarrhoea and positive C jejuni serology. Electrophysiological characteristics in C jejuni related cases were compared with those in viral related GBS patients. In addition, eight GBS patients from another cohort with positive stool cultures for C jejuni were analysed. Results: 17 (14%) of 123 patients had C jejuni related GBS. C jejuni patients had lower motor and higher sensory action potentials compared with viral related cases. Nine (53%) C jejuni patients had either AMAN or inexcitable nerves. However, three (18%) patients fulfilled the criteria for acute inflammatory demyelinating polyneuropathy (AIDP). Also, two (25%) of eight additional patients with a C jejuni positive stool sample had AIDP. Conclusion: In The Netherlands, C jejuni infections are strongly, but not exclusively, associated with axonal GBS. Some patients with these infections fulfil current criteria for demyelination.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1136/jnnp.2010.226639
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1136/jnnp.2010.226639
dc.description.sourcetitleJournal of Neurology, Neurosurgery and Psychiatry
dc.description.volume82
dc.description.issue3
dc.description.page300-305
dc.description.codenJNNPA
dc.identifier.isiut000287351900014
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