Please use this identifier to cite or link to this item: https://doi.org/10.1161/STROKEAHA.110.609339
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dc.titleSafety and outcomes of intravenous thrombolysis in stroke mimics: A 6-year, single-care center study and a pooled analysis of reported series
dc.contributor.authorTsivgoulis, G.
dc.contributor.authorAlexandrov, A.V.
dc.contributor.authorChang, J.
dc.contributor.authorSharma, V.K.
dc.contributor.authorHoover, S.L.
dc.contributor.authorLao, A.Y.
dc.contributor.authorLiu, W.
dc.contributor.authorStamboulis, E.
dc.contributor.authorAlexandrov, A.W.
dc.contributor.authorMalkoff, M.D.
dc.contributor.authorFrey, J.L.
dc.date.accessioned2016-07-08T09:27:11Z
dc.date.available2016-07-08T09:27:11Z
dc.date.issued2011-06
dc.identifier.citationTsivgoulis, G., Alexandrov, A.V., Chang, J., Sharma, V.K., Hoover, S.L., Lao, A.Y., Liu, W., Stamboulis, E., Alexandrov, A.W., Malkoff, M.D., Frey, J.L. (2011-06). Safety and outcomes of intravenous thrombolysis in stroke mimics: A 6-year, single-care center study and a pooled analysis of reported series. Stroke 42 (6) : 1771-1774. ScholarBank@NUS Repository. https://doi.org/10.1161/STROKEAHA.110.609339
dc.identifier.issn00392499
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125449
dc.description.abstractBackground And Purpose- Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determine safety and to describe outcomes of intravenous thrombolysis in SM. Methods- We retrospectively analyzed stroke registry data of consecutive acute ischemic stroke admissions treated with intravenous thrombolysis over a 6-year-period. The admission National Institutes of Health Stroke Scale score, vascular risk factors, ischemic lesions on brain MRI (routinely performed as part of diagnostic work-up), and discharge modified Rankin Scale scores were documented. Initial stroke diagnosis in the emergency department was compared with final discharge diagnosis. SM diagnosis was based on the absence of ischemic lesions on diffusion-weighted imaging sequences in addition to an alternate discharge diagnosis. Symptomatic intracranial hemorrhage was defined as brain imaging evidence of intracranial hemorrhage with clinical worsening by National Institutes of Health Stroke Scale score increase of 4 points. Results- Intravenous thrombolysis was administered in 539 patients with acute ischemic stroke (55% men; mean age, 66±15 years). Misdiagnosis of acute ischemic stroke was documented in 56 cases (10.4%; 95% CI, 7.9% to 13.3%). Conversion disorder (26.8%), complicated migraine (19.6%), and seizures (19.6%) were the 3 most common final diagnoses in SM. SMs were younger (mean age, 56±13 years) and had milder baseline stroke severity (median National Institutes of Health Stroke Scale, 6; interquartile range, 4) compared with patients with confirmed acute ischemic stroke (mean age, 67±14 years; median National Institutes of Health Stroke Scale, 8; interquartile range, 10; P
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1161/STROKEAHA.110.609339
dc.sourceScopus
dc.subjectintracranial hemorrhage
dc.subjectischemic stroke
dc.subjectoutcome
dc.subjectstroke mimics
dc.subjectthrombolysis
dc.subjecttPA
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1161/STROKEAHA.110.609339
dc.description.sourcetitleStroke
dc.description.volume42
dc.description.issue6
dc.description.page1771-1774
dc.description.codenSJCCA
dc.identifier.isiut000291032700065
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