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|Title:||Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma||Authors:||Pan, J.
epidermal growth factor receptor
vascular endothelial growth factor
|Issue Date:||Sep-2013||Citation:||Pan, J., Tang, T., Xu, L., Lu, J.J., Lin, S., Qiu, S., Chen, G., Tham, I.W.K. (2013-09). Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head and Neck 35 (9) : 1238-1247. ScholarBank@NUS Repository. https://doi.org/10.1002/hed.23116||Abstract:||Background The association between expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and the long-term outcomes in treated nasopharyngeal carcinoma (NPC) was studied. Methods Expression of COX-2, VEGF, and EGFR by immunohistochemical (IHC) staining was assessed in 128 patients with NPC. Overall survival (OS), disease-free survival (DFS), locoregional control, and distant metastasis-free survival rates were compared for different expression levels of each marker. Multivariate analysis was by the Cox regression model. Results Median follow-up after radiation therapy ± chemotherapy was 116 months. Univariate and multivariate analyses demonstrated that COX-2, VEGF, EGFR, and clinical stage were all independent predictors for OS, DFS, locoregional control, and distant metastasis-free survival rates. Conclusions High expression of COX-2, VEGF, and EGFR were independent adverse prognostic factors for long-term outcomes in nonmetastatic NPC independent of clinical stage. © 2012 Wiley Periodicals, Inc.||Source Title:||Head and Neck||URI:||http://scholarbank.nus.edu.sg/handle/10635/125438||ISSN:||10433074||DOI:||10.1002/hed.23116|
|Appears in Collections:||Staff Publications|
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