Please use this identifier to cite or link to this item: https://doi.org/10.1002/hed.23116
Title: Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma
Authors: Pan, J.
Tang, T.
Xu, L.
Lu, J.J. 
Lin, S.
Qiu, S.
Chen, G.
Tham, I.W.K. 
Keywords: cyclooxygenase 2
epidermal growth factor receptor
nasopharyngeal neoplasms
prognosis
vascular endothelial growth factor
Issue Date: Sep-2013
Citation: Pan, J., Tang, T., Xu, L., Lu, J.J., Lin, S., Qiu, S., Chen, G., Tham, I.W.K. (2013-09). Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head and Neck 35 (9) : 1238-1247. ScholarBank@NUS Repository. https://doi.org/10.1002/hed.23116
Abstract: Background The association between expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and the long-term outcomes in treated nasopharyngeal carcinoma (NPC) was studied. Methods Expression of COX-2, VEGF, and EGFR by immunohistochemical (IHC) staining was assessed in 128 patients with NPC. Overall survival (OS), disease-free survival (DFS), locoregional control, and distant metastasis-free survival rates were compared for different expression levels of each marker. Multivariate analysis was by the Cox regression model. Results Median follow-up after radiation therapy ± chemotherapy was 116 months. Univariate and multivariate analyses demonstrated that COX-2, VEGF, EGFR, and clinical stage were all independent predictors for OS, DFS, locoregional control, and distant metastasis-free survival rates. Conclusions High expression of COX-2, VEGF, and EGFR were independent adverse prognostic factors for long-term outcomes in nonmetastatic NPC independent of clinical stage. © 2012 Wiley Periodicals, Inc.
Source Title: Head and Neck
URI: http://scholarbank.nus.edu.sg/handle/10635/125438
ISSN: 10433074
DOI: 10.1002/hed.23116
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