Please use this identifier to cite or link to this item:
|Title:||Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma||Authors:||Pan, J.
epidermal growth factor receptor
vascular endothelial growth factor
|Issue Date:||Sep-2013||Citation:||Pan, J., Tang, T., Xu, L., Lu, J.J., Lin, S., Qiu, S., Chen, G., Tham, I.W.K. (2013-09). Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head and Neck 35 (9) : 1238-1247. ScholarBank@NUS Repository. https://doi.org/10.1002/hed.23116||Abstract:||Background The association between expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and the long-term outcomes in treated nasopharyngeal carcinoma (NPC) was studied. Methods Expression of COX-2, VEGF, and EGFR by immunohistochemical (IHC) staining was assessed in 128 patients with NPC. Overall survival (OS), disease-free survival (DFS), locoregional control, and distant metastasis-free survival rates were compared for different expression levels of each marker. Multivariate analysis was by the Cox regression model. Results Median follow-up after radiation therapy ± chemotherapy was 116 months. Univariate and multivariate analyses demonstrated that COX-2, VEGF, EGFR, and clinical stage were all independent predictors for OS, DFS, locoregional control, and distant metastasis-free survival rates. Conclusions High expression of COX-2, VEGF, and EGFR were independent adverse prognostic factors for long-term outcomes in nonmetastatic NPC independent of clinical stage. © 2012 Wiley Periodicals, Inc.||Source Title:||Head and Neck||URI:||http://scholarbank.nus.edu.sg/handle/10635/125438||ISSN:||10433074||DOI:||10.1002/hed.23116|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 5, 2020
WEB OF SCIENCETM
checked on Aug 5, 2020
checked on Jul 31, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.