Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0061949
Title: Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy
Authors: Winston, A.
Arenas-Pinto, A.
Stöhr, W.
Fisher, M.
Orkin, C.M.
Aderogba, K.
De Burgh-Thomas, A.
O'Farrell, N.
Lacey, C.J.N.
Leen, C.
Dunn, D.
Paton, N.I. 
Issue Date: 30-Apr-2013
Citation: Winston, A., Arenas-Pinto, A., Stöhr, W., Fisher, M., Orkin, C.M., Aderogba, K., De Burgh-Thomas, A., O'Farrell, N., Lacey, C.J.N., Leen, C., Dunn, D., Paton, N.I. (2013-04-30). Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy. PLoS ONE 8 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0061949
Abstract: Objective:To describe factors associated with neurocognitive (NC) function in HIV-positive patients on stable combination antiretroviral therapy.Design:We undertook a cross-sectional analysis assessing NC data obtained at baseline in patients entering the Protease-Inhibitor-Monotherapy-Versus-Ongoing-Triple therapy (PIVOT) trial.Main outcome measure:NC testing comprised of 5 domains. Raw results were z-transformed using standard and demographically adjusted normative datasets (ND). Global z-scores (NPZ-5) were derived from averaging the 5 domains and percentage of subjects with test scores >1 standard deviation (SD) below population means in at least two domains (abnormal Frascati score) calculated. Patient characteristics associated with NC results were assessed using multivariable linear regression.Results:Of the 587 patients in PIVOT, 557 had full NC results and were included. 77% were male, 68% Caucasian and 28% of Black ethnicity. Mean (SD) baseline and nadir CD4+ lymphocyte counts were 553(217) and 177(117) cells/μL, respectively, and HIV RNA was
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/125419
ISSN: 19326203
DOI: 10.1371/journal.pone.0061949
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