Please use this identifier to cite or link to this item: https://doi.org/10.1002/cncr.28324
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dc.titleNeoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: Interim results from 2 prospective phase 2 clinical trials
dc.contributor.authorKong, L.
dc.contributor.authorHu, C.
dc.contributor.authorNiu, X.
dc.contributor.authorZhang, Y.
dc.contributor.authorGuo, Y.
dc.contributor.authorTham, I.W.K.
dc.contributor.authorLu, J.J.
dc.date.accessioned2016-07-08T09:26:47Z
dc.date.available2016-07-08T09:26:47Z
dc.date.issued2013-12-01
dc.identifier.citationKong, L., Hu, C., Niu, X., Zhang, Y., Guo, Y., Tham, I.W.K., Lu, J.J. (2013-12-01). Neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: Interim results from 2 prospective phase 2 clinical trials. Cancer 119 (23) : 4111-4118. ScholarBank@NUS Repository. https://doi.org/10.1002/cncr.28324
dc.identifier.issn0008543X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125417
dc.description.abstractBACKGROUND The authors studied the efficacy of neoadjuvant chemotherapy, consisting of a taxane, cisplatin, and 5-fluorouracil (5-FU) (the TPF regimen) followed by concurrent chemoradiation, in 2 separately designed and synchronously executed phase 2 trials for stage III and IVA/IVB nasopharyngeal cancer (NPC). METHODS Patients with newly diagnosed NPC were accrued to 2 trials, 1 for patients with stage III disease and the other for patients with IVA/IVB disease. All patients received TPF (docetaxel 75 mg/m2, cisplatin 75 mg/m2, and 5-FU 2500 mg/m2 every 3 weeks for 3 cycles) followed by cisplatin 40 mg/m2 per week concurrently with either 3-dimentional conformal radiation therapy or intensity-modulated radiation therapy. RESULTS From January 2007 to July 2011, 52 eligible patients with stage III NPC and 64 eligible patients with nonmetastatic stage IV NPC were accrued. With a median follow-up of 32.9 months, the 3-year overall survival rates were 94.8% (95% confidence interval [CI], 87.6%-100%) and 90.2% (95% CI, 81.8%-98.6%) for the stage III NPC group and the IVA/IVB NPC group, respectively. The 3-year progression-free survival, distant metastasis-free survival, and local progression-free survival rates were 78.2% (95% CI, 64.6%-91.8%), 90.5% (95% CI, 79.7%-100%), and 93.9%(87.1%-100%), respectively, for patients with stage III NPC and 85.1% (95% CI, 75.1%-95.1%), 88% (95% CI, 78.6%-97.4%), and 100%, respectively, for patients with stage IVA/IVB NPC. The most common severe (grade 3/4) hematologic and nonhematologic adverse events were neutropenia (64 patients; 55.2%) and nausea/vomiting (23 patients; 19.8%). CONCLUSIONS Neoadjuvant TPF followed by concurrent chemoradiation was well tolerated and produced encouraging outcomes in patients with locally advanced NPC in this hypothesis-generating study. The authors concluded that randomized controlled trials are warranted to definitively confirm this aggressive and potentially efficacious strategy. © 2013 American Cancer Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/cncr.28324
dc.sourceScopus
dc.subjectchemotherapy
dc.subjectconcurrent chemoradiation
dc.subjectnasopharyngeal carcinoma
dc.subjectradiotherapy
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1002/cncr.28324
dc.description.sourcetitleCancer
dc.description.volume119
dc.description.issue23
dc.description.page4111-4118
dc.description.codenCANCA
dc.identifier.isiut000327832800010
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