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Title: Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia
Authors: Takeuchi, S.
Matsushita, M.
Zimmermann, M.
Ikezoe, T.
Komatsu, N.
Seriu, T.
Schrappe, M.
Bartram, C.R.
Koeffler, H.P. 
Keywords: ALL
Multiple genes
Issue Date: Oct-2011
Citation: Takeuchi, S., Matsushita, M., Zimmermann, M., Ikezoe, T., Komatsu, N., Seriu, T., Schrappe, M., Bartram, C.R., Koeffler, H.P. (2011-10). Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia. Leukemia Research 35 (10) : 1345-1349. ScholarBank@NUS Repository.
Abstract: Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age (p = 0.01 and p = 0.03, respectively). Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL (p = 0.02 and p = 0.01, respectively). In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL (p = 0.01). Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk (p = 0.004 and p = 0.03, respectively). These results suggest that methylation status is associated with clinicopathological features in childhood ALL. © 2011 Elsevier Ltd.
Source Title: Leukemia Research
ISSN: 01452126
DOI: 10.1016/j.leukres.2011.04.015
Appears in Collections:Staff Publications

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