Please use this identifier to cite or link to this item: https://doi.org/10.1128/JVI.01156-13
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dc.titleInhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice
dc.contributor.authorSridharan, A.
dc.contributor.authorChen, Q.
dc.contributor.authorTang, K.F.
dc.contributor.authorOoi, E.E.
dc.contributor.authorHibberd, M.L.
dc.contributor.authorChenb, J.
dc.date.accessioned2016-07-08T07:19:48Z
dc.date.available2016-07-08T07:19:48Z
dc.date.issued2013
dc.identifier.citationSridharan, A., Chen, Q., Tang, K.F., Ooi, E.E., Hibberd, M.L., Chenb, J. (2013). Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. Journal of Virology 87 (21) : 11648-11658. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.01156-13
dc.identifier.issn0022538X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/125301
dc.description.abstractA characteristic clinical feature of dengue virus infection is thrombocytopenia, though its underlying mechanism is not definitively determined. By adoptive transfer of human CD34+ fetal liver cells into immunodeficient mice, we have constructed humanized mice with significant levels of human platelets, monocytes/macrophages, and hepatocytes. Infection of these mice with both lab-adapted and clinical strains of dengue virus induces characteristic human hematological changes, including transient leukopenia and thrombocytopenia. We show that the specific depletion of human platelets is not mediated by antibodies in the periphery or reduced production of human thrombopoietin in the liver but reduction of human megakaryocytes and megakaryocyte progenitors in the bone marrow of the infected mice. These findings identify inhibition of platelet production in the bone marrow as a key mechanism underlying dengue-induced thrombocytopenia and suggest the utility of the improved humanized mouse model in studying dengue virus infection and pathogenesis in a human cell context. © 2013, American Society for Microbiology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/JVI.01156-13
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1128/JVI.01156-13
dc.description.sourcetitleJournal of Virology
dc.description.volume87
dc.description.issue21
dc.description.page11648-11658
dc.description.codenJOVIA
dc.identifier.isiut000325863400029
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