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Title: Type II enteropathy-associated T-cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group
Authors: Tse, E.
Gill, H.
Loong, F.
Kim, S.J.
Ng, S.-B. 
Tang, T.
Ko, Y.-H.
Chng, W.-J. 
Lim, S.-T. 
Kim, W.S.
Kwong, Y.-L.
Issue Date: Jul-2012
Citation: Tse, E., Gill, H., Loong, F., Kim, S.J., Ng, S.-B., Tang, T., Ko, Y.-H., Chng, W.-J., Lim, S.-T., Kim, W.S., Kwong, Y.-L. (2012-07). Type II enteropathy-associated T-cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group. American Journal of Hematology 87 (7) : 663-668. ScholarBank@NUS Repository.
Abstract: Enteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3 + (100%), CD56 + (91%), TIA-1 + (96%), CD4 -CD8 + (63%), CD4 +CD8 + (19%), CD4 -CD8 - (16%), and CD4 +CD8 - (3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P = 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). © 2012 Wiley Periodicals, Inc.
Source Title: American Journal of Hematology
ISSN: 03618609
DOI: 10.1002/ajh.23213
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