Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/125068
Title: | APPLICATIONS OF PHOSPHINE CATALYSIS IN ENANTIOSELECTIVE ANNULATIONS OF ALKYNE DERIVATIVES | Authors: | WONG YEE LIN | Keywords: | phosphine, alkynes, enantioselective, annulation, cyclopentene | Issue Date: | 23-Dec-2015 | Citation: | WONG YEE LIN (2015-12-23). APPLICATIONS OF PHOSPHINE CATALYSIS IN ENANTIOSELECTIVE ANNULATIONS OF ALKYNE DERIVATIVES. ScholarBank@NUS Repository. | Abstract: | PHOSPHINE-CATALYZED ANNULATIONS FORM THE PIONEER STUDY OF ORGANOCATALYZED ENANTIOSELECTIVE TRANSFORMATIONS AND HAVE DEMONSTRATED EXCELLENT REACTIVITY AND SELECTIVITY IN MANY EXAMPLES. HIGHLY FUNCTIONALIZED CYCLOPENTENE SCAFFOLD IS AN IMPORTANT FEATURE IN NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE MOLECULES; THE ACHIEVEMENT OF SUCH SCAFFOLD IS A DRIVING FORCE FOR THE EXTENSIVE EXPLORATION OF ORGANOCATALYTIC SYSTEMS.CHIRAL AMINO ACID-BASED PHOSPHINE CATALYSTS ARE EMPLOYED TO INVESTIGATE THEIR CATALYTIC CAPABILITY FOR ENANTIOSELECTIVE ANNULATION OF ALKYNES. ALKYNES ARE MORE STABLE THAN ALLENES AND REPRESENT A CLASS OF VERSATILE BUILDING BLOCKS. TWO HIGHLY ENANTIOSELECTIVE PHOSPHINE-CATALYZED [3+2] ANNULATIONS OF INTERNAL UNACTIVATED ALKYNES WITH ELECTRON-DEFICIENT OLEFINS SUCH AS A,B-UNSATURATED KETONE ESTERS AND ARYLIDENEOXINDOLES ARE ACHIEVED, FORMING FUNCTIONALIZED CYCLOPENTENE SCAFFOLDS IN GOOD TO EXCELLENT REGIO- AND ENANTIOSELECTIV | URI: | http://scholarbank.nus.edu.sg/handle/10635/125068 |
Appears in Collections: | Ph.D Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
WONGYL.pdf | 7.74 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.