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https://doi.org/10.1021/jm300677j
DC Field | Value | |
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dc.title | Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases | |
dc.contributor.author | Rose, N.R. | |
dc.contributor.author | Woon, E.C.Y. | |
dc.contributor.author | Tumber, A. | |
dc.contributor.author | Walport, L.J. | |
dc.contributor.author | Chowdhury, R. | |
dc.contributor.author | Li, X.S. | |
dc.contributor.author | King, O.N.F. | |
dc.contributor.author | Lejeune, C. | |
dc.contributor.author | Ng, S.S. | |
dc.contributor.author | Krojer, T. | |
dc.contributor.author | Chan, M.C. | |
dc.contributor.author | Rydzik, A.M. | |
dc.contributor.author | Hopkinson, R.J. | |
dc.contributor.author | Che, K.H. | |
dc.contributor.author | Daniel, M. | |
dc.contributor.author | Strain-Damerell, C. | |
dc.contributor.author | Gileadi, C. | |
dc.contributor.author | Kochan, G. | |
dc.contributor.author | Leung, I.K.H. | |
dc.contributor.author | Dunford, J. | |
dc.contributor.author | Yeoh, K.K. | |
dc.contributor.author | Ratcliffe, P.J. | |
dc.contributor.author | Burgess-Brown, N. | |
dc.contributor.author | Von Delft, F. | |
dc.contributor.author | Muller, S. | |
dc.contributor.author | Marsden, B. | |
dc.contributor.author | Brennan, P.E. | |
dc.contributor.author | McDonough, M.A. | |
dc.contributor.author | Oppermann, U. | |
dc.contributor.author | Klose, R.J. | |
dc.contributor.author | Schofield, C.J. | |
dc.contributor.author | Kawamura, A. | |
dc.date.accessioned | 2016-06-02T10:29:58Z | |
dc.date.available | 2016-06-02T10:29:58Z | |
dc.date.issued | 2012-07-26 | |
dc.identifier.citation | Rose, N.R., Woon, E.C.Y., Tumber, A., Walport, L.J., Chowdhury, R., Li, X.S., King, O.N.F., Lejeune, C., Ng, S.S., Krojer, T., Chan, M.C., Rydzik, A.M., Hopkinson, R.J., Che, K.H., Daniel, M., Strain-Damerell, C., Gileadi, C., Kochan, G., Leung, I.K.H., Dunford, J., Yeoh, K.K., Ratcliffe, P.J., Burgess-Brown, N., Von Delft, F., Muller, S., Marsden, B., Brennan, P.E., McDonough, M.A., Oppermann, U., Klose, R.J., Schofield, C.J., Kawamura, A. (2012-07-26). Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry 55 (14) : 6639-6643. ScholarBank@NUS Repository. https://doi.org/10.1021/jm300677j | |
dc.identifier.issn | 00222623 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/125028 | |
dc.description.abstract | The JmjC oxygenases catalyze the N-demethylation of N ε- methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups. © 2012 American Chemical Society. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/jm300677j | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PHARMACY | |
dc.description.doi | 10.1021/jm300677j | |
dc.description.sourcetitle | Journal of Medicinal Chemistry | |
dc.description.volume | 55 | |
dc.description.issue | 14 | |
dc.description.page | 6639-6643 | |
dc.description.coden | JMCMA | |
dc.identifier.isiut | 000306764600036 | |
Appears in Collections: | Staff Publications |
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